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Patent # Description
2019/0218595 SELECTIVE LYSIS OF CELLS
Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is...
2019/0218594 COMBINED MULTIPLE-DISPLACEMENT AMPLIFICATION AND PCR IN AN EMULSION MICRODROPLET
The methods and systems described herein provide an improved emulsion droplet based nucleic acid amplification method, which allows nucleic acids contained in...
2019/0218593 SILICONE SURFACTANTS FOR EMULSION ASSAYS
System, including methods and compositions, for making and using emulsions that include a silicone oil and a silicone surfactant. The emulsions may include...
2019/0218592 COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the...
2019/0218591 SYSTEMS AND METHODS FOR SCHEDULING AND SEQUENCING AUTOMATED TESTING PROCEDURES
Automated Antimicrobial Susceptibility Testing (AST) systems and methods are provided in which samples are passed through one or more recursive or ...
2019/0218590 Methods and Systems for the Rapid Detection of Cronobacter Using Infectious Agents
Disclosed herein are methods and systems for rapid detection of microorganisms such as Cronobacter spp. in a sample. A genetically modified bacteriophage is...
2019/0218589 Methods and Systems for the Rapid Detection of Salmonella Using Infectious Agents
Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which...
2019/0218588 NOVEL CELL CULTURE METHOD, CELL CULTURE SYSTEM AND USES THEREOF
A method is disclosed wherein human organ cells (e.g. hepatocytes) are cultured in human plasma medium (e.g., 70% to 100% human plasma) in place of the...
2019/0218587 SCREENING METHOD FOR CANDIDATE SUBSTANCES FOR ACTIVE COMPONENT TO PREVENT OR TREAT AT LEAST ONE DISEASE...
This invention provides a device for screening a candidate substance for an active ingredient to prevent or treat declined kidney function etc. A screening...
2019/0218586 METHODS FOR ENZYMATIC PEPTIDE LIGATION
The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is...
2019/0218585 High-Throughput Enzymatic Preparation of Glucosylated Steviol Glycosides under Programming Temperatures
The present invention discloses a method for preparing glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high...
2019/0218584 Enzyme Compositions and Uses Thereof
The present invention relates to enzyme compositions and processes of producing and using the compositions for the saccharification of lignocellulosic material.
2019/0218583 POLYSACCHARIDE-OXIDIZING COMPOSITION AND USES THEREOF
The invention relates to a polysaccharide-oxidizing composition comprising a polysaccharide-oxidizing enzyme wherein, when the said polysaccharide-oxidizing...
2019/0218582 SIALYLTRANSFERASES AND USES THEREOF
Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides.
2019/0218581 Methods of Degrading or Hydrolyzing a Polysaccharide
The invention provides a method of degrading or hydrolyzing a polysaccharide, preferably cellulose or chitin, comprising contacting said polysaccharide with...
2019/0218580 PREPARATION OF 6-AMINOCAPROIC ACID FROM 5-FORMYL VALERIC ACID
The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as `6-ACA`) using a biocatalyst. The invention further...
2019/0218579 METHOD FOR PRODUCING OXO FATTY ACID AND RARE FATTY ACID
The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid,...
2019/0218578 MICROBIAL ORGANISMS FOR CONVERTING ACETYL-COA INTO CROTYL ALCOHOL AND METHODS FOR PRODUCING CROTYL ALCOHOL
The present invention provides microorganisms capable of converting acetyl-coA into crotyl alcohol as well as fermentation methods for producing crotyl...
2019/0218577 METHODS, SYNTHETIC HOSTS AND REAGENTS FOR THE BIOSYNTHESIS OF ISOPRENE AND DERIVATIVES
Methods and compositions for synthesizing dienes and derivative thereof, such as isoprene, in Cupriavidus necator are provided.
2019/0218576 PROCESS FOR HYDROGEN PRODUCTION FROM GLYCEROL
The present document describes a process for production of hydrogen gas (H.sub.2) from fermentation of crude glycerol with a hydrogen producing microorganism...
2019/0218575 SELF-ITERATING EXOSOMAL VECTOR FOR EFFECTIVE BIOMOLECULAR TRANSFERS
The present invention provides for a process for transferring biomolecules such as polynucleotides and protein from cell to cell, eventually resulting in the...
2019/0218574 METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer...
2019/0218573 HIV PRE-IMMUNIZATION AND IMMUNOTHERAPY
The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo...
2019/0218572 METHOD FOR PROPAGATING STERILE MALE PLANT LINE
A method for maintaining a male sterile plant in a homozygous recessive state includes providing a first plant that includes homozygous recessive male...
2019/0218571 CMV RESISTANCE ALLELE
The present invention relates to an allele designated alpha-CMV which confers resistance to CMV when present in a spinach plant, wherein the protein encoded by...
2019/0218570 White Rust Resistant Chrysanthemum Plants
The present invention relates to white rust resistant plants of the genus Chrysanthemum and to seeds, plant parts, plant cells and progeny thereof. The present...
2019/0218569 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USING SAME FOR INCREASING PLANT YIELD, BIOMASS, GROWTH...
Provided are isolated polynucleotides encoding a polypeptide at least 80% homologous to the amino acid sequence selected from the group consisting of SEQ ID...
2019/0218568 OILS, LIPIDS AND FATTY ACIDS PRODUCED IN TRANSGENIC BRASSICA PLANT
The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said...
2019/0218567 OILS, LIPIDS AND FATTY ACIDS PRODUCED IN TRANSGENIC BRASSICA PLANT
The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said...
2019/0218565 NUCLEIC ACID CONSTRUCTS, PLANTS WITH INCREASED TUBER YIELD, AND METHODS FOR INCREASING TUBER YIELD IN A PLANT
The present invention relates to a nucleic acid construct. The nucleic acid construct includes a nucleic acid molecule configured to silence or reduce the...
2019/0218564 TOBACCO PLANT AND METHOD FOR MANUFACTURING SAME
The present invention provides a tobacco plant which is suitable for cultivation for harvesting leaf tobaccos. The present invention includes (i) a tobacco...
2019/0218563 Compositions and Methods for Altering Flowering and Plant Architecture to Improve Yield Potential
The present invention provides recombinant DNA constructs, vectors and molecules comprising a polynucleotide sequence encoding a florigenic FT protein operably...
2019/0218562 PLANT TRANSFORMATION WITHOUT SELECTION
The invention provides methods for identifying regenerated transformed plants and differentiated transformed plant parts, obtained without subjecting plant...
2019/0218561 METHODS OF HOST CELL MODIFICATION
Described herein are novel methods of inserting nucleic acid sequences into host cells. Also described herein are genetically stable host cells comprising...
2019/0218560 METHODS AND COMPOSITIONS FOR REGULATION OF TRANSGENE EXPRESSION
Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived...
2019/0218559 siRNA knocking down Human PD-1 and Recombinant Expression CAR-T Vector and Their Construction Methods and...
Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same, A PD-1...
2019/0218558 THERAPEUTIC COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
Disclosed herein are polynucleotide agents (including interfering RNA agents (RNAi)), small molecule agents, and synthetic cells, methods of making the same,...
2019/0218557 INHIBITION OF PCSK9 THROUGH RNAI
The invention relates to various PCSK9 RNAi constructs with gene silencing activities, and uses thereof. The construct has a double-stranded region of 19-49...
2019/0218556 COMPOSITIONS AND METHODS OF INHIBITING GENE EXPRESSION IN A LUNG
The present invention provides compositions and methods for delivery to a lung tissue comprising a small interfering RNA (siRNA) capable of inhibiting...
2019/0218555 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING MICRORNA AS ACTIVE INGREDIENT
The present invention relates to a pharmaceutical composition for treatment of cancer, which comprises, as an active ingredient, one or more miRNAs selected...
2019/0218554 Mixed Tricyclo-DNA, 2'-Modified RNA Oligonucleotide Compositions and Uses Thereof
In some embodiments, disclosed herein are oligomeric compounds which include one or more tricyclo-deoxyribonucleic acid (tc-DNA) nucleosides and one or more...
2019/0218553 VON WILLEBRAND FACTOR (VWF)-TARGETING AGENTS AND METHODS OF USING THE SAME
Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also...
2019/0218552 CHEMICALLY MODIFIED SINGLE-STRANDED RNA-EDITING OLIGONUCLEOTIDES
The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA...
2019/0218551 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3' and/or 5'-end groups are provided. The disclosed compounds are useful...
2019/0218550 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF COMPLEMENT COMPONENT 5(C5) BY DOUBLE-STRANDED RNA
This invention relates to compounds, compositions, and methods useful for reducing C5 target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate...
2019/0218549 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter...
2019/0218548 Method for Producing N-acetylglucosamine by Co-utilizing Glucose and Xylose Based on CRISPRi
The present invention discloses a method for producing N-acetylglucosamine (GlcNAc) by co-utilizing glucose and xylose based on CRISPRi, and belongs to the...
2019/0218547 STRUCTURE-ENGINEERED GUIDE RNA
The invention provides a modified guide RNA comprising an extension sequence, as well as related compositions and methods.
2019/0218546 MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE
The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies....
2019/0218545 NUCLEIC ACID INDEXING TECHNIQUES
Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic...
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