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Patent # Description
US-9,896,454 Microbiocidal heterobicyclic derivatives
Compounds of the formula (I), wherein Y--X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, A.sup.1, A.sup.2, A.sup.3, Ra and n areas...
US-9,896,453 Purinone derivative hydrochloride
The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-di- hydro-8H-purin-8-one hydrochloride has Btk-selective...
US-9,896,452 Substituted prolines/piperidines as orexin receptor antagonists
The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX.sub.1 or OX.sub.2, or both; to pharmaceutical...
US-9,896,451 Method for producing endo-9-azabicyclo[3.3.1]nonan-3-ol derivative
A 9-azabicyclo[3.3.1]nonan-3-one derivative is reacted with a hydrogen in the presence of a catalyst composed of a ruthenium complex to obtain, at a low cost,...
US-9,896,450 Modulators of Clavibacter michiganensis and methods of making and using thereof
The subject matter disclosed herein generally relates to modulators of Clavibacter michiganensis subsp. michiganensis, derivatives thereof, formulations...
US-9,896,449 Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## a method for manufacturing said compound,...
US-9,896,448 Pyrimido[4,5-b]quinoline-4,5(3H, 10H)-dione derivatives
The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its...
US-9,896,447 TrkA kinase inhibitors, compositions and methods thereof
The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence...
US-9,896,446 Azaquinazoline inhibitors of atypical protein kinase C
The present application provides a compound of formula (I) ##STR00001## or a salt thereof, wherein R.sup.7, R.sup.8, R.sup.9, G, and X are as defined herein....
US-9,896,445 Heterocyclic inhibitors of ERK1 and ERK2 and their use in the treatment of cancer
The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these...
US-9,896,444 Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
The present invention relates to compounds of formula (I): ##STR00001## in which Y, Y.sub.1, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the Summary...
US-9,896,443 Perforin inhibiting benzenesulfonamide compounds, preparation and uses thereof
Compounds of formula (1a) and pharmaceutically acceptable salts, solvates, and hydrates thereof and related methods of modulatin perforin activity on a cell:...
US-9,896,442 Antifungal treatment
A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective...
US-9,896,441 Tetrahydroquinoline sulfonamide and related compounds for use as agonists of ROR.gamma. and the treatment of...
The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions,...
US-9,896,440 Aryl substituted heterocyclyl sulfones
The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these...
US-9,896,439 Pyrazole-substituted arylamides as P2X.sub.3 and P2X.sub.2/3 antagonists
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted pyrazolyl, and R.sup.2,...
US-9,896,438 2,2,2-trifluoroethyl-thiadiazines
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
US-9,896,437 Diarylhydantoin compounds
The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
US-9,896,436 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted ...
US-9,896,435 N-pyrrolidinyl,N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R.sup.1, R.sup.2, R.sup.a,...
US-9,896,434 Substituted indanone compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and...
The present invention relates to indanone compounds. The indanone compounds are GPR119 modulators and useful for the prevention and/or treatment of diabetes,...
US-9,896,433 Antiviral compounds
The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical...
US-9,896,432 Somatostatin modulators and uses thereof
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
US-9,896,431 Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
The present invention provides compounds of Formula (I): ##STR00001## a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, a solvate...
US-9,896,430 Process for the preparation of 3-(3-CHLORO-1H-pyrazol-1-yl)pyridine
This disclosure relates to the field of preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine and intermediates therefrom. These intermediates are useful in the...
US-9,896,429 Nicotine salts, co-crystals, and salt co-crystal complexes
The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular,...
US-9,896,428 Process for preparing chloroacetaldehyde acetals
The invention relates to a process for preparing chloroacetaldehyde acetals of monohydric, dihydric or higher-functionality aliphatic alcohols, in which the...
US-9,896,427 Liquid crystal composition and liquid crystal display including the same
A liquid crystal composition including at least one of the liquid crystal molecules represented by Chemical Formulas 1 to 3: ##STR00001##
US-9,896,426 Extraction separation method of a flavone component based on graphene
The present invention refers to the technical field of flavone component extraction, and provides an extraction separation method of a flavone component based...
US-9,896,425 Process for purifying an acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic...
An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid...
US-9,896,424 Methods of making sulfurized derivatives
This disclosure relates to sulfurized derivatives made from functionalized monomers. The disclosure relates to lubricants, functional fluids, fuels,...
US-9,896,423 Deuterium substituted 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine compound or derivatives thereof, and...
The present disclosure provides a deuterium substituted 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine compound with a structure represented by formula...
US-9,896,422 Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits
The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably the scaffold of tetracycline or minocycline,...
US-9,896,421 Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof
Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening...
US-9,896,420 N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and...
The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been...
US-9,896,419 Compositions and methods of treating retinal disease
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin,...
US-9,896,418 Aryl ethers and uses thereof
The present disclosure relates to HIF-2.alpha. inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in...
US-9,896,417 Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- ...
The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-diflu- ...
US-9,896,416 Piperidinium quaternary salts
There are described new 1-alkyl-1-methyl-4-[(2,2-diphenyl-2-propoxy)acetoxy]piperidinium halides and pharmaceutical compositions comprising a ...
US-9,896,415 Chalcone derivatives having an anti-allergic activity
The present invention relates to the compounds of formula (I): ##STR00001## wherein: R.sub.2, R.sub.4 and R.sub.6, either identical or different, represent a...
US-9,896,414 Covalently patterned graphene surfaces by a force accelerated cycloaddition reaction
The present invention relates generally to molecular printing techniques for use in sensors, assays, and integrated optics and electronics. Specifically, the...
US-9,896,413 Ionizable cationic lipid for RNA delivery
What is described is a compound of formula I ##STR00001## wherein R.sub.1 is a linear alkyl, alkenyl, or alkynyl of 2 to 12 carbons, or a branched alkyl with...
US-9,896,412 Reagents and method for conjugating biological molecules
A compound of the general formula X-[Q-W--(CH.dbd.CH).sub.n--(CH.sub.2).sub.2-L].sub.m (I) in which X represents a polymer; Q represents a linking group; W...
US-9,896,411 Characterization of the cocrystal products formed by metoprolol and dabigatran bases with L-theanine
Methods of making cocrystal compositions of metoprolol and dabigatran bases with enantiomers of theanine.
US-9,896,410 Process for the recovery of betaine from molasses
A process for the recovery of betaine from a raw material consisting essentially of molasses. The process includes a demineralization step, a conversion step...
US-9,896,409 Purification of cadaverine using high boiling point solvent
One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile...
US-9,896,408 Method for producing azido-amine derivative
A method for producing an azido-amine derivative includes obtaining an azido-amine derivative and extracting the azido-amine derivative obtained by using an...
US-9,896,407 Exhaust gas cleaning in a method for continuously producing dinitrotoluene
The invention relates to a method for producing dinitrotoluene, comprising the following steps: a) nitrating toluene with a mixture of nitric acid and sulfuric...
US-9,896,406 Method for producing 2-methylbutyric acid having a reduced content of 3-methylbutyric acid from the secondary...
A process for preparing 2-methylbutyric acid having a reduced content of 3-methylbutyric acid from the secondary streams obtained in the preparation of...
US-9,896,405 Methods for the production of .alpha.,.beta.-unsaturated carboxylic acids and salts thereof
Processes for producing an .alpha.,.beta.-unsaturated carboxylic acid, such as acrylic acid, or a salt thereof, using treated solid oxides are disclosed. The...
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