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Patent # Description
US-9,920,055 Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors
Provided are certain fused tricyclic urea compounds and salts thereof, compositions thereof, and methods of use therefor.
US-9,920,054 Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR.gamma....
US-9,920,053 N-(hetero)aryl-substituted heteroyclic derivatives useful for the treatment of diseases or conditions related...
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
US-9,920,052 Imidazopyridine derivatives as modulators of TNF activity
A series of substituted 1H imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
US-9,920,051 Key intermediates and impurities of the synthesis of apixaban: apixaban glycol esters
Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction....
US-9,920,050 Fused heterocyclic compound and pest control use thereof
A fused heterocyclic compound is provided represented by the following formula (1) or an N-oxide thereof, wherein A.sup.1 represents NR.sup.5, oxygen or sulfur,...
US-9,920,049 Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Y are as...
US-9,920,048 Substituted pyrimidines for inhibiting Raf kinase activity
The present invention provides methods of inhibiting Raf kinase activity in a patient, the method comprising administering to the patient a compound having...
US-9,920,047 Cyclopropanamine compound and use thereof
The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or...
US-9,920,046 Oxime-substituted amide compound and pest control agent
To provide a novel pesticide, especially a fungicide and a nematocide. An oxime-substituted amide compound represented by the formula (I) or its salt, and a...
US-9,920,045 Solid state forms of a PDE10 inhibitor
The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,- ...
US-9,920,044 Selective androgen receptor modulators
This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient,...
US-9,920,043 Crystalline form of 6-[(4R)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]iosoquinoline-1-carb- onitrile
This invention relates to a novel crystalline form of 6-[(4R)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbo- nitrile which is useful as a...
US-9,920,042 Compounds for use in the treatment of mycobacterial infections
The present invention concerns compounds of general formula (I): ##STR00001## in which Y and Z are chosen from CH and N; T is chosen from CO or SO.sub.2; n is...
US-9,920,041 Compositions and methods for inhibition of the JAK pathway
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in...
US-9,920,040 GPR40 agonists for the treatment of type II diabetes
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
US-9,920,039 1,2,4-Oxadiazol compounds active against gram-positive pathogens
The present invention relates to new oxazolidinone compounds of general formula (I) having antibiotic activity even against multiresistant bacterial strains...
US-9,920,038 Methyl oxazole orexin receptor antagonists
The present invention is directed to methyloxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
US-9,920,037 Diaryl isoxazoline compound
The present invention concerns compounds of formula (I) or an N-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or...
US-9,920,036 Cyanoamino (aza)benzofuran compounds for the treatment of hepatitis C
Compounds of Formula (I), including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
US-9,920,035 Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation...
The present invention relates to compounds of general formula (I) ##STR00001## and the tautomers and the salts thereof, particularly the pharmaceutically...
US-9,920,034 Crystalline forms of a factor XIa inhibitor
The instant invention provides crystalline forms of (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(- ...
US-9,920,033 Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
The present invention relates to a crystalline form of N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,- ...
US-9,920,032 Heterocyclic compounds useful as pim kinase inhibitors
The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to...
US-9,920,031 Indole carboxamide compounds
Disclosed are compounds of Formula (I): ##STR00001## or a salt thereof, wherein: X is CR.sub.4 or N; R.sub.1, R.sub.2, R.sub.3, R.sub.4, and A are defined...
US-9,920,030 Fungicidal azocyclic amides
Disclosed are compounds of Formulae 1, 1A, 1B and 1C including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein R.sup.1,...
US-9,920,029 Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
US-9,920,028 Cationic lipid
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R.sup.1 and...
US-9,920,027 4'-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
Provided are 4'-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods...
US-9,920,026 Amide derivatives, process for preparation thereof and use thereof as insecticide
A compound represented by Formula (1): ##STR00001## The compound can be used as insecticides.
US-9,920,025 Antibiotic
The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said...
US-9,920,024 Method for purifying compound or resin
The method according to the present invention is a method for purifying a compound represented by a specific formula (1) or a resin having a structure...
US-9,920,023 Leveling composition and method for electrodeposition of metals in microelectronics
The present disclosure relates to a leveling composition for electrodepositing metals. The composition comprises a compound of formula (I): ##STR00001##
US-9,920,022 Small molecule compound and synthesizing method and uses thereof
Provided is a small molecule compound as represented by structural formula (I). The product of the present invention in various concentrations and dosages can...
US-9,920,021 Method of preparing vortioxetine
The new method of preparing 1-(2-(2,4-di-methylphenylsulphanyl)phenyl)piperazine of formula (I) or its salt comprises a reaction of ...
US-9,920,020 Using squaraine dyes as near infrared fluorescent sensors for protein detection
Squaraine dyes are used to detect the presence of protein in a test sample, which is a substance that may contain protein. A squarine dye is placed in water,...
US-9,920,019 Multifunctional composition base 1,3-oxazinan-6-ones with corrosion inhibition and heavy organic compounds...
Base compounds including 1,3-oxazinan-6-one derivatives of N-alkyl or N-alkenyl or N-cycloalkyl or N-aryl propionic acids and paraformaldehyde, and their...
US-9,920,018 Fused heterocyclic compounds as ion channel modulators
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
US-9,920,017 Heterocyclic compounds as pesticides
The present application relates to novel heterocyclic compounds, to the use thereof for controlling animal pests including arthropods, insects and nematodes,...
US-9,920,016 Process for the preparation of 4-amino ...
Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3 -hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one(13, RX-3117) and its ...
US-9,920,015 Methods for preparing azoxystrobin and intermediate thereof
The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound...
US-9,920,014 Selective inhibition of bacterial topoisomerase I
The present invention provides novel bisbenzimidazole compounds and methods of using the compounds as antibacterial agents.
US-9,920,013 2,5-dioxoimidazolidin-1-yl-3-urea derivatives as formyl peptide modulators
The present invention relates to 1-(2,5-dioxoimidazolidin-1-yl)-3-substituted urea compounds, processes for preparing them, pharmaceutical compositions...
US-9,920,012 Indazole guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
The invention provides indazole guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using indazole guanidine compounds as therapeutic agents...
US-9,920,011 Enhanced erythropoiesis and iron metabolism
The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron...
US-9,920,010 CXCR7 receptor modulators
The present invention relates to derivatives of formula (I) ##STR00001## wherein (R.sup.1).sub.n, R.sup.2a, R.sup.2b, R.sup.3a, R.sup.3b, R.sup.4, L.sup.1,...
US-9,920,009 UV absorbing compounds, compositions comprising same and uses thereof
There is provided a range of novel compounds which have been demonstrated to have useful UV absorbing properties. These compounds will find use in a range of...
US-9,920,008 Catalyst for synthesizing ethylenimine as well as preparation method and application thereof
The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst...
US-9,920,007 Process for the preparation of 1-(2,6,6-trimethylcyclohexyl)-alkan-3-ols
The present invention relates to a process for the preparation of 1-(2,6,6-trimethylcyclohexylyalkan-3-ols, in particular ...
US-9,920,006 Prepolymers exhibiting rapid development of physical properties
Hydroxyl-containing bis(alkenyl) ethers can be incorporated into the backbone of polythioether prepolymers and can be used as curing agents in thiol-terminated...
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