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Patent # Description
US-9,950,074 Composition and delivery vehicle for active agents and methods therefor
A vehicle composition in the form of a vesicular composition or a particular composition and, optionally, an active agent associated with the vesicle forming...
US-9,950,073 Peptide sequence design and use thereof for peptide-mediated siRNA delivery
Peptides that have been found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets are...
US-9,950,072 Controlled release formulations for the delivery of HIF-1 inhibitors
Controlled release dosage formulations for the delivery of one or more HIF-1 inhibitors are provided. The controlled release formulations contain one or more...
US-9,950,071 Hybrid anticancer prodrug simultaneously producing cinnamaldehyde and quinone methide and method for preparing same
The present invention relates to a hybrid anticancer prodrug simultaneously producing cinnamaldehyde and quinone methide. The hybrid anticancer prodrug...
US-9,950,070 HER2 aptamer-anticancer drug complex for cancer cell chemotherapy
This invention relates to a complex for cancer cell chemotherapy and, more particularly, to a HER2 aptamer-anticancer drug complex for chemotherapy of cancer...
US-9,950,069 Material and method for treating internal cavities
A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to...
US-9,950,068 Delivery and formulation of engineered nucleic acids
Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression....
US-9,950,067 Trans carotenoids, their synthesis, formulation and uses
The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These...
US-9,950,066 Formulation of human antibodies for treating TNF-alpha associated disorders
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
US-9,950,065 Particles comprising a shell with RNA
The present invention relates to RNA decorated particles such as RNA decorated lipid particles, preferably to RNA decorated liposomes. Further, the present...
US-9,950,064 Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof
The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to ...
US-9,950,063 Vaccine composition containing synthetic adjuvant
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery...
US-9,950,062 Compounds and compositions as TLR activity modulators
The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such...
US-9,950,061 Porcine epidemic diarrhea virus vaccine
The present invention relates to a vaccine for protecting a pig against diseases associated with porcine epidemic diarrhea virus. The vaccine commonly includes...
US-9,950,060 Biochemically stabilized HIV-1 Env trimer vaccine
Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly...
US-9,950,059 Immunogenic composition
Recombinant chimeric viruses based on NDV LaSota strain and containing either ILTV gB or gD are produced. Administration of the chimeric viruses to chickens...
US-9,950,058 RSV F protein mutants
The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein...
US-9,950,057 High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an...
US-9,950,056 Compositions, methods and kits for eliciting an immune response
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in...
US-9,950,055 Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides...
US-9,950,054 Glycoconjugation processes and compositions
The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ...
US-9,950,053 Use of the Salmonella SPP type III secretion proteins as a protective vaccination
Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization...
US-9,950,052 Compositions produced using enteric pathogens and methods of use
The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or...
US-9,950,051 Formulations
This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix...
US-9,950,050 Vaccines based on hepatitis B core antigens
The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sugar attached to an e1 loop. The protein may comprise a first and a second...
US-9,950,049 Composition and therapeutic anti-tumour vaccine
The invention relates to a composition which induces, in a host, a cytotoxic cell response directed against cells expressing an antigen, in particular tumor...
US-9,950,048 Immunogenic epitopes for immunotherapy
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-9,950,047 XBP1, CD138, and CS1 peptides, pharmaceutical compositions that include the peptides, and methods of using such...
The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in...
US-9,950,046 Methods of treatment using alpha-1-antitrypsin compositions
A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the...
US-9,950,045 Method of treating depression
Methods are disclosed herein for treating depression in the subject. A method includes the use of Botulinum toxin to cause paralysis of a facial muscle, such as...
US-9,950,044 Treatment of pulmonary vascular remodeling with neprilysin
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic...
US-9,950,043 Modulation of muscle and adipocyte distribution and fate
Modulation of the ADAMTS1 signaling pathway alters the commitment of progenitor cells to a muscle fate; and increases muscle mass.
US-9,950,042 Extended length botulinum toxin formulation for human or mammalian use
An extended duration pharmaceutical composition including a botulinum neurotoxin, an adhesive agent, and a stabilizing macromolecule is disclosed. The...
US-9,950,041 Therapeutic charge engineered variants of lysozyme and methods for using same to treat infections
The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrodial activity, relative...
US-9,950,040 Cell-free DNA as a therapeutic target for female infertility and diagnostic marker
The present invention pertains to the use of DNase to treat female infertility and the use of cfDNA as a marker of female infertility.
US-9,950,039 Insulin glargine/lixisenatide fixed ratio formulation
The present invention refers to a pharmaceutical composition comprising (a) lixisenatide or/and a pharmaceutically acceptable salt thereof, and (b) insulin...
US-9,950,038 Methods and compositions for inhibiting delayed graft function
Disclosed are compositions and methods for inhibiting preventing, reducing delayed graft function, allograft rejection or ischemia reperfusion injury.
US-9,950,037 Enhancing progenitor cell numbers
Therapies using IL-18 alone or in combination with IL-7 for rebuilding weakened immune systems by increasing progenitor cell yields from bone marrow stem cells...
US-9,950,036 Treatment of mood and stress related disorders
A pharmaceutical composition and method for treating or attenuating a mood or stress-related disorder in a subject having normal or low inflammatory state is...
US-9,950,035 Methods and non-immunogenic compositions for treating inflammatory disorders
Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a...
US-9,950,034 Methods for preventing or treating disorders by increasing bioavailability of iron and related pharmaceutical...
The present disclosure relates to methods of treating, ameliorating or preventing a disorder comprising administering a therapeutically effective amount of a...
US-9,950,033 Use of engrailed proteins for increasing dopamine synthesis by dopaminergic neurons
The invention relates to the use of an Engrailed protein as a medicament for increasing dopamine synthesis by dopaminergic neurons, in particular in the...
US-9,950,032 Compositions and methods for lung regeneration
Airway stem cells have been implicated in the pathology and progression of chronic airway diseases and yet also hold the promise of physiological and ultimately...
US-9,950,031 Hatching fluid enzymes and uses thereof
The present invention relates to various polypeptides from fish hatching fluid, their encoding nucleic acid sequences, pharmaceutical compositions comprising...
US-9,950,030 Treatment and diagnosis of ocular disease
This invention concerns compositions and methods of treating or diagnosing ocular disease.
US-9,950,029 Method of treating or preventing benign prostatic hyperplasia using modified pore-forming proteins
The present invention provides a method of treating BPH using modified pore-forming proteins (MPPs). These MPPs are derived from naturally occurring cytotoxic...
US-9,950,028 Uses of starch binding protein (SBP)-tagged immunostimulatory protein
The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering...
US-9,950,027 Peptide analogues with branched amino acid probe(s)
The present invention relates to peptide analogs comprising one or more branched amino acid probes and a peptide, native or variants thereof.
US-9,950,026 Methods for reducing oxidative damage
The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an...
US-9,950,024 Traditional Chinese medicine composition and the use thereof
The present invention relates to the technical field of Traditional Chinese medicine, in particular to a traditional Chinese medicine composition and the use...
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