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Patent # Description
US-9,951,344 Exogenous terminators for controlling fungal gene expression
Provided herein are exogenous terminator sequences for use in fungi cell transcriptional termination.
US-9,951,343 Process for recombinant protein expression augmentation in Bacillus expression system
A process for efficient expression of a foreign gene in a Bacillus host was developed by varying the length and nucleotide sequence in the spacer region between...
US-9,951,342 Cultures with improved phage resistance
The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product...
US-9,951,341 Lactococcus CRISPR-Cas sequences
The present invention relates to a nucleic acid comprising a Lactococcus CRISPR repeat region and/or a Lactococcus CRISPR spacer region.
US-9,951,340 Compositions and methods for bacterial delivery of polypeptides
The methods and compositions described herein relate to the delivery of polypeptides to a target cell, e.g. by utilizing engineered non-pathogenic bacteria...
US-9,951,339 Cell modification method using essential genes as markers and optionally recycling these
The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus,...
US-9,951,338 siRNA and their use in methods and compositions for inhibiting the expression of the PDK1 gene
The invention relates to siRNA molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the PDK1 gene. The invention...
US-9,951,337 Methods and means for treatment of osteoarthritis
The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically,...
US-9,951,336 Composition for reducing senescence of cell or subject comprising smurf2 inhibitor and use thereof
A composition for reducing a level of senescence of a cell or subject, a method of reducing a level of senescence in a cell or subject by using the composition,...
US-9,951,335 Compositions and methods for treating otitis media and other conditions with inhibitors of CYLD
The present invention is based, in part, on our studies of molecular pathways that include the deubiquitinase CYLD. Accordingly, the present invention features,...
US-9,951,334 Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological...
US-9,951,333 Antisense design
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
US-9,951,332 SnoRNA, compositions and uses
The present invention concerns the use of particular RNA sequences as a medicament. More precisely, it concerns the use of small nucleolar RNAs (snoRNAs) which...
US-9,951,331 Targeting microRNA-26a/b for the treatment of neurodegenerative disease
Methods for treating a neurodegenerative disorder associated with aggregation of tau protein in the brain of a subject, comprising administering to the subject...
US-9,951,330 Micrornas that silence tau expression
This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with...
US-9,951,329 Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles
The present invention relates to compositions of virus-like particles for the introduction of RNA-interference (RNAi-) inducing molecules into eukaryotic cells...
US-9,951,328 Gene vector
A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a...
US-9,951,327 Efficient and rapid method for assembling and cloning double-stranded DNA fragments
The invention is directed to an in vitro method for joining a first set of double-stranded (ds) DNA molecules. Small molecules acting as chaperone agents are...
US-9,951,326 Enhancing microbial metabolism of C5 organic carbon
Provided herein are recombinant microorganisms having two or more copies of a nucleic acid sequence encoding xylose isomerase, wherein the nucleic acid encoding...
US-9,951,325 Serine protease molecules and therapies
Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of...
US-9,951,324 PSMA binding ligand-linker conjugates and methods for using
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents....
US-9,951,323 Pullulanase chimeras and polynucleotides encoding same
The present invention relates to hybrid polypeptides having pullulanase activity, and polynucleotides encoding the polypeptides. The invention also relates to...
US-9,951,322 Methods and compositions related to thioesterase enzymes
The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of...
US-9,951,320 DNA polymerases with improved activity
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful...
US-9,951,319 Polypeptides having peroxygenase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates...
US-9,951,318 Ketoreductase polypeptides for the reduction of acetophenones
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme....
US-9,951,317 Highly efficient influenza matrix (M1) proteins
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also...
US-9,951,316 Enhancers of induced pluripotent stem cell reprogramming
Described herein, inter alia, are methods and compositions useful for induced pluripotent stem cell reprogramming.
US-9,951,315 Immortalization of epithelial cells and methods of use
The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte...
US-9,951,314 Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present...
US-9,951,313 Methods and uses for ex vivo tissue culture systems
The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device...
US-9,951,312 Method for preparation of cartilage cell
Chondrocytes are prepared from perichondrocytes. The present invention provides a cell derived from a perichondrial tissue, the cell being capable of...
US-9,951,311 Agents and methods to elicit anti-tumor immune response
The invention provides an isolated, purified population of human cells comprising CD8.sup.+ T cells with reduced Cbl-b activity. The invention provides uses of...
US-9,951,310 Methods of using IL-21 for adoptive immunotherapy and identification of tumor antigens
Methods for preparing ex vivo T cell cultures using IL-21 compositions for use in adoptive immunotherapy are described. Addition of IL-21 to cultures of...
US-9,951,309 Stem cell packaging and shipping
This invention concerns methods of packaging and shipping stem cells. Also disclosed are related package products.
US-9,951,308 Temperature-responsive cell culture substrate and method for producing same
Provided is a cell culture substrate, in which polymer (B) having a lower critical solution temperature contained in the substrate is a copolymer of a monomer...
US-9,951,307 Method for producing fungus structures
A method for growing organically derived building materials in the form of a moldable substrate that can be engineered to serve a wide range of manufacturing...
US-9,951,306 Catalase in growth media
The present invention relates to the use of a secreted fungal catalase, for hydrogen-peroxide neutralization in growth media for the detection of microorganisms...
US-9,951,305 Cell culture device and transport device
The present invention provides a carrier device including a culture vessel and a flow channel, which have a closed structure, for supplying cell liquid or a...
US-9,951,304 Cleaning pack
Multi-compartment water-soluble pack comprising a cleaning composition and an enveloping material where the pack comprises a first compartment containing a...
US-9,951,303 Compositions for grafting fragrance substances
This disclosure relates to composition for grafting fragrance substances, as well as related articles, consumer products, and methods.
US-9,951,302 Label removal solution for low temperature and low alkaline conditions
According to the invention, the compositions and methods provide for the complete removal of synthetic glues or adhesives from a plurality of surfaces through...
US-9,951,301 Solid free-flowing particulate laundry detergent composition
A solid free-flowing particulate laundry detergent composition comprising: (a) from 0.1 wt % to 5 wt % hueing agent particle comprising: (i) from 2 wt % to 10...
US-9,951,300 Laundry detergent
Liquid laundry detergent compositions containing a microcapsule with a cationically charged coating and a fluorescent brightener with a distyrylbiphenyl unit,...
US-9,951,299 Cutinase variants and polynucleotides encoding same
The present invention relates to variants with cutinase activity of a parent cutinase, comprising an alteration at one or more (e.g. several) positions...
US-9,951,298 Fluorescent brightener premix
A fluorescent brightener premix comprising from 1% to 15% of a fluorescent brightener and 10% to 80% of an alkoxylated nonionic surfactant, by weight of the...
US-9,951,297 Detergent composition compromising a cationic polymer containing a vinyl formamide nonionic structural unit
Fabric care compositions comprising a cationic polymer, a silicone, and a surfactant system. Methods of making and using such compositions.
US-9,951,296 Solid free-flowing particulate laundry detergent composition
A solid free-flowing particulate laundry detergent composition including: (a) from 0.5 wt % to 20 wt % ethoxylated alkyl sulphate particle including: (i) from...
US-9,951,295 Compositions for deposition on biological surfaces
A sucrose polyester composition that imparts a coating providing a slickness to teeth when delivered from an oral care composition.
US-9,951,294 Coated microcapsules
Accordingly, there are provided coated microcapsules including: a microcapsule including a polymeric shell and a liquid core material encapsulated therein; and...
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