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Patent # Description
US-9,969,805 Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers...
The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to...
US-9,969,804 Methods and compositions for treating and preventing disease associated with alpha-V beta-8 integrin
Antibodies (e.g., isolated antibodies) that specifically bind to human integrin .beta.8 and inhibit adhesion of latency associated peptide (LAP) to...
US-9,969,803 Monoclonal antibodies that inhibit the Wnt signaling pathway and methods of production and use thereof
Monoclonal antibodies against LRP6 and that block the Wnt signaling pathway are disclosed. Methods of production and use thereof are also disclosed.
US-9,969,802 Method for detecting malignant tumor cells
Provided is a detection method for a malignant tumor cell, including measuring a protein marker expressed on a malignant tumor cell surface. The detection...
US-9,969,801 Cell, method and kit for conducting an assay for neutralizing antibodies
The present invention provides a cell for use in a one-step cell-based assay for an extracellular ligand (e.g., IFN.alpha.) that initiates a ligand-specific...
US-9,969,800 IL-8 antibodies
One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative...
US-9,969,799 Anti-human proBDNF monoclonal antibody, and uses thereof in pains
The present invention provides an anti-human proBDNF monoclonal antibody, and uses thereof in pains. Specifically, the present invention provides uses of...
US-9,969,798 Modulators and methods of use
Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
US-9,969,796 Peptides and binding partners therefor
The invention provides a peptide obtainable from C. albicans as well as variants and fragments thereof, and labelled forms of these. The peptide is immunogenic...
US-9,969,795 Means and methods for producing high affinity antibodies
The invention provides means and methods for producing high-affinity antibodies against an antigen of interest, usually stable B-cell cultures.
US-9,969,794 HA binding agents
This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses,...
US-9,969,793 Compositions and methods for the treatment of immunodeficiency
The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the...
US-9,969,792 Methods and compositions for producing a chimeric polypeptide
The present invention provides methods and compositions for converting a first polypeptide into a chimeric polypeptide. The invention includes two vectors: a...
US-9,969,791 Modified fibronectin fragments or variants and uses thereof
The present invention provides isolated polypeptides comprising a modified fibronectin fragment that comprises FNIII 10 and optionally further comprising FNIII...
US-9,969,790 Compositions and methods for immunomodulation in an organism
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need...
US-9,969,789 Treatment of CD47+ disease cells with SIRP alpha-Fc fusions
CD47+ disease cells, such as CD47+ cancer cells, are treated with an agent that blocks signalling via the SIRP.alpha./CD47 axis. The agent is a human...
US-9,969,788 Methods of treating damaged cartilage tissue using growth factors fused to heparin binding sequences
The present invention is directed to proteins in which a heparin binding peptide is fused to a growth factor that promotes cell growth and survival. The...
US-9,969,787 Glucagon-like-peptide-2 (GLP-2) analogues
GLP-2 analogs are disclosed which comprise one of more substitutions as compared to h[Gly2]GLP-2 and which may have the property of an altered GLP-1 activity,...
US-9,969,786 Trophic hormone fusion protein, preparation method and application thereof
Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof....
US-9,969,785 Biglycan mutants and related therapeutics and methods of use
The present disclosure provides compositions and methods for treating diseases or conditions associated with an abnormal level or activity of biglycan;...
US-9,969,784 Compositions and methods for modulation of immune function
Compositions and methods for modulating immune cell function and Nedd-4 family member signaling are disclosed.
US-9,969,783 Opsin polypeptides and methods of use thereof
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
US-9,969,782 Highly immunogenic peptides derived from the human immunodeficiency virus V2 region
The present invention relates to an isolated immunogenic peptide chimera comprising a first peptide moiety comprising the amino acid sequence of SEQ ID NO: 1,...
US-9,969,781 Compositions and methods to treat cancer with CpG rich DNA and cupredoxins
The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The...
US-9,969,780 Tat complexes, and vaccines comprising them
Complexes comprising HIV Tat and the V3 loop from gp120 Env provide novel epitopes and are immunogenic to prevent or inhibit infection by HIV.
US-9,969,779 Polynucleotides for treating oncogenic viral polypeptide positive tumors
This document relates to polynucleotides encoding antigenic polypeptides to induce an immune response to oncogenic viral polypeptides. Also provided are...
US-9,969,778 Influenza virus vaccines and uses thereof
The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1...
US-9,969,777 Mutant spike protein extending the tissue tropism of infectious bronchitis virus (IBV)
The present invention provides an infectious bronchitis virus (IBV) spike protein (S protein) which is based on an S protein from an IBV strain with restricted...
US-9,969,776 Drug conjugates for delivering compounds to senescent cells
Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of...
US-9,969,775 CGRP antagonist peptides
This disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## in which m, p, A, Ar.sup.1, Ar.sup.2,...
US-9,969,774 Cell penetrating peptide and method for delivering biologically active substance using same
The present disclosure is directed to providing: a new cell-penetrating peptide; and a composition for delivering a biologically active substance, a composition...
US-9,969,773 Polymers, pharmaceutical compositions and methods of synthesizing the same
Novel methods to prepare novel polymers are disclosed. Oxazolidinyl compounds according to formula IV: ##STR00001## are also disclosed as intermediate...
US-9,969,772 Covalent granzyme B inhibitors
Covalent Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. A method for treating cutaneous scleroderma,...
US-9,969,771 Tetrapeptide having effect of inhibiting VEGF-induced angiogenesis and use thereof
Provided are a tetrapeptide for inhibiting VEGF-induced angiogenesis and a use thereof, and particularly, provided is a peptide having the amino acid sequence...
US-9,969,770 Proline compounds as Granzyme B inhibitors
Proline compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous...
US-9,969,769 Coupling method for peptide synthesis at elevated temperatures
An improved method for coupling amino acids into peptides or peptidomimetics is disclosed that includes the steps of combining an amino acid, a carbodiimide, an...
US-9,969,768 Oleanolic acid methyl ester derivatives
Oleanolic acid methyl ester derivatives demonstrate potent anti-diabetic activities. In in vitro anti-diabetic testing, the derivatives showed more potency...
US-9,969,767 Oxolupene derivatives
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid...
US-9,969,766 20(R)-ginsenoside Rg3 polyacylated derivatives, preparation and application thereof
The present invention provides 20(R)-ginsenoside Rg3 polyacylated derivatives of the formula (I) and preparation method and anti-tumor application thereof: ...
US-9,969,765 Nuclions and ribocapsids
The invention relates to an isolated nuclion having (i) a core nucleic acid, and (ii) one or more ribocapsids each including a polymer of two or more ribocapsid...
US-9,969,764 Dithiolane functionalized nucleoside amidites and supports for stronger immobilization of bio-molecules on...
This invention is related to nucleic acid chemistry and describes novel 1,2-dithiolane functionalized nucleoside phosphoramidites (1, Chart 1) and corresponding...
US-9,969,763 1,2,3-triazole-tethered carbohydrate-di and tri lipidated cysteine conjugates useful as vaccine adjuvants and...
The present invention relates to carbohydrate-di and tri lipidated cysteine based 1,2,3-triazoles useful as vaccine adjuvants of formula 1 ##STR00001## The...
US-9,969,762 Method for synthesizing N-alkyl-glycosyl(di)amine derivatives and uses of same against phytopathogens
The present invention relates to a novel method for synthesizing, without a solvent, N-alkyl-glycosyl(di)amine derivatives represented by the following general...
US-9,969,761 Stabilisation of radiopharmaceutical precursors
The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as...
US-9,969,760 Method for lignin recovery
The present invention primarily relates to a method for isolating lignin, preferably unmodified lignin, from a mixture, in particular a pulping slurry,...
US-9,969,759 Duplex-selective organometallic DNA intercalators
Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.
US-9,969,758 Antimicrobial compounds
An antimicrobial compound, as well as the salts, derivatives and analogs thereof, said compound being represented by the general formula (I): ##STR00001## ...
US-9,969,757 Ionic compounds having a silyloxy group
There is provided an ionic compound having attached thereto a silyloxy group. There is also provided methods of making this ionic compound as well as...
US-9,969,756 Carbosilane substituted amine precursors for deposition of Si-containing films and methods thereof
Disclosed are Si-containing film forming compositions comprising carbosilane substituted amine precursors. The carbosilane substituted amine precursors have the...
US-9,969,755 Photodynamic therapy photosensitizers
A compound of formula (I) useful as a photosensitizer in photodynamic therapy is provided. There is also provided a photosensitizing composition for use in...
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