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Patent # Description
US-9,975,949 Anti-CD79b antibodies and methods of use
The invention provides anti-CD79b antibodies and methods of using the same.
US-9,975,948 Isolation and purification of anti-IL-13 antibodies using protein A affinity chromatography
Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an...
US-9,975,946 Antibodies obtainable using supramolecular constructs
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive...
US-9,975,945 Passive immunisation against influenza, in particular H5N1
The invention relates to a composition comprising immunoglobulins specific to influenza virus and produced through immunization of a producer animal, for use as...
US-9,975,944 Synthetic peptides for the treatment of autoimmune diseases
The present invention provides synthetic peptides, including peptides comprising a plurality of epitopes, each epitope being derived from a different protein,...
US-9,975,943 Polypeptides
The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as...
US-9,975,942 EPHA3 And multi-valent targeting of tumors
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments,...
US-9,975,941 Method for purifying teriparatide
The present invention relates to a novel method for purifying teriparatide, a therapeutically active polypeptide fragment of full-length human parathyroid...
US-9,975,940 Long-acting single-chain insulin analogues
A single-chain insulin analogue containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29...
US-9,975,939 Glucagon analogues
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular,...
US-9,975,938 Long-acting polypeptides and methods of producing and administering same
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest...
US-9,975,937 Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia
The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with ...
US-9,975,936 Nucleic acids encoding modified FGF-21 polypeptides comprising non-naturally occurring amino acids
Modified FGF-21 polypeptides and uses thereof are provided.
US-9,975,935 NEIL3 peptides and vaccines including the same
The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes...
US-9,975,934 Follistatin-related fusion proteins
In certain aspects, the present disclosure provides compositions and methods for inhibiting activity of TGF.beta. superfamily ligands, particularly ligands such...
US-9,975,933 Tumor tissue-penetrating peptide specific to neuropilin and fusion protein having same peptide fused therein
A tumor tissue-penetrating peptide specifically binding to neuropilin, or a fusion protein, a small molecule drug, a nanoparticle, or a liposome having the...
US-9,975,932 Variants of group 5 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline...
The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterized by...
US-9,975,931 Use of an immunomodulatory protein from Ganoderma in promoting neurite outgrowth
The inventors surprisingly found that an immunomodulatory protein from Ganoderma can promote neurite outgrowth, suggesting that the immunomodulatory protein...
US-9,975,930 Lantibiotic derivatives and process for their preparation
The present invention concerns novel antibiotic compounds, which are lantibiotics, the processes for their preparation, their pharmaceutically acceptable salts,...
US-9,975,929 Recombinant clostridial neurotoxins with increased duration of effect
This invention relates to novel recombinant clostridial neurotoxins exhibiting increased duration of effect and to methods for the manufacture of such...
US-9,975,928 Heparosan-producing bacterium and heparosan manufacturing method
A method for producing heparosan is provided. Heparosan is produced by culturing an Escherichia bacterium having a heparosan-producing ability and modified so...
US-9,975,927 Mutant fragments of OspA and methods and uses relating thereto
The present invention relates to compositions and methods for the prevention and treatment of Borrelia infection. Particularly, the present invention relates to...
US-9,975,926 Methods of making and using vaccines utilizing minicircle DNA expression vectors for production of...
This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the...
US-9,975,925 Influenza antigens and antibodies
Novel influenza antigens, novel immunogenic or vaccine compositions, as well as uses of and methods for producing said antigens and compositions, are described.
US-9,975,924 Approach to produce HIV-1 GP140 envelope protein trimers
An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers...
US-9,975,923 Methods and compositions for norovirus blockade epitopes
The present invention provides methods and compositions comprising a chimeric norovirus capsid protein comprising a norovirus VP1 major capsid protein backbone...
US-9,975,922 Peptide inhibitor of HIV reverse transcription
Disclosed are peptides that exhibit good binding to the anticodon stem and loop of human lysine tRNA species, tRNALys3. The starting point was the 15-amino-acid...
US-9,975,921 Crystal forms of anamorelin
Crystalline forms of anamorelin which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and...
US-9,975,920 Purification of immunoglobulins from plasma
The present invention relates to the purification of target molecules like immunoglobulins from plasma. The use of a certain type of ion exchanger based on a...
US-9,975,919 Methods for reducing aggregate content in protein preparations
A method of reducing aggregate and product-contaminant complex content in a protein preparation including a desired protein includes (i) contacting the protein...
US-9,975,918 Highly potent glucocorticoids
The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these...
US-9,975,917 Pentacyclic triterpenoidal derivatives
A pentacyclic triterpenoidal derivative can include 3,11-dioxo-24(phenyl)-urs-12-en-24-one (4), 24-norurs-12-en-24(phenyl)-3,11-dione (5), ...
US-9,975,916 Compositions and methods relating to complex nucleic acid nanostructures
The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are...
US-9,975,915 Crystalline forms of nicotinoyl ribosides, modified derivatives thereof, and phosphorylated analogs thereof,...
The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): ##STR00001## wherein X.sup.-, Z.sup.1,...
US-9,975,914 Antimicrobial preparation and uses thereof
A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of a preparation...
US-9,975,913 Method for in-gel visual detection of bioanalytes
The present invention relates to a method for in-gel visual detection and quantitative detection of proteins in activity based protein profiling (ABPP) using...
US-9,975,912 Method for producing (E,Z)-7,9-dodecadienyl-1-acetate
The present invention concerns a method to access (E,Z)-7,9-dodecadienyl-1-acetate in two synthesis steps with excellent yields and selectivity greater than 70%...
US-9,975,911 Antibacterial compounds and biological applications thereof
The invention relates to compounds of formulae (Ia), (Ib) or (Ic) wherein, A.sub.1 and A.sub.2, identical or different, are H, (C.sub.1-C.sub.6) alkyl,...
US-9,975,910 Hetero-fused cyclic compound
A compound represented by the formula (I) or a salt thereof: ##STR00001## wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two...
US-9,975,909 Polyether alcohols bearing alkoxysilyl groups by alkoxylation of epoxy-functional alkoxysilanes over double...
Polyether alcohols having alkoxysilyl groups, the use thereof and a process for their preparation by means of DMC catalysis, characterized in that one or more...
US-9,975,908 Metal oxide precursors, coating compositions containing same, and use thereof
The present invention relates to metal oxide precursors comprising i) at least one metal atom selected from the group consisting of In, Ga, Zn and Sn, ii) at...
US-9,975,907 Pyrimidinones as PI3K inhibitors
The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases...
US-9,975,906 Tricyclic heterocycle derivatives having HIV replication inhibitory effect
The present invention provides the following compound having anti-HIV activity of formula: ##STR00001## wherein, A.sup.1 is C, CR.sup.1A or N; A.sup.2 is C,...
US-9,975,905 Derivatized 3-styryl-cephalosporins
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
US-9,975,904 Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes
Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): ##STR00001## ...
US-9,975,903 Condensed heterocyclic compound
The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of...
US-9,975,902 Compounds for the inhibition of cyclophilins and uses thereof
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of...
US-9,975,901 Crystalline solid state form of the benzene sulphonic acid salt of ...
The present invention relates to a salt form of a benzodiazepine derivative, in particular crystalline solid state forms, to pharmaceutical compositions...
US-9,975,900 Substituted imidazo[1,2-.alpha.]pyrazines for treating spinal muscular atrophy
The present invention provides compounds of formula (I) ##STR00001## wherein A, X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as...
US-9,975,899 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines...
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines...
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