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Patent # Description
US-9,975,898 Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-YL)-3,4-dihydropyr- azino...
Provided herein are formulations, processes, solid forms and methods of use relating to the compound of formula (I): ##STR00001## having the name...
US-9,975,897 Pyrazolopyrimidine derivatives useful as inhibitors of Bruton's tyrosine kinase
This invention relates to compounds of formula (I). The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention...
US-9,975,896 Inhibitors of transcription factors and uses thereof
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae...
US-9,975,895 Substituted pyrimidinium compounds and derivatives for combating animal pests
Substituted pyrimidinium compounds of the general formula (I) and their uses for combating animal pests The present invention relates to substituted...
US-9,975,894 Heterocyclic compounds and uses thereof
Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their...
US-9,975,893 Pyrazolo[3,4-c]pyridine derivatives
Disclosed are a compound of formula (I), a tautomer, an optical isomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition...
US-9,975,892 Anxiolytic compounds
The present invention relates to chemical compounds of general formula (I) ##STR00001## which may possess useful therapeutic activity in a range of central...
US-9,975,891 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P.sub.4--P-M-M.sub.4 I or pharmaceutically acceptable salt...
US-9,975,890 Bicyclic AZA compounds as muscarinic M1 receptor antagonists
This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1...
US-9,975,889 Heteroaryl piperidine and heteroaryl piperazine derivatives as fungicides
Heteroarylpiperidine and -piperazine derivatives of the formula (I) ##STR00001## in which the symbols A, X, Y, L.sup.1, L.sup.2, G, Q, p, R.sup.1, R.sup.2 and...
US-9,975,888 Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of...
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other...
US-9,975,887 Compounds as ROR gamma modulators
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R.sup.1, R.sup.2,...
US-9,975,886 Potassium channel modulators
Provided are compounds of the formula: ##STR00001## ##STR00002## and pharmaceutically acceptable salts and compositions thereof, which are useful for...
US-9,975,885 Broad-spectrum non-covalent coronavirus protease inhibitors
This invention pertains to materials and methods for the treatment of patients with coronavirus infection and the control of zoonotic disease outbreaks using...
US-9,975,884 Kojic acid-derived mannich bases with biological effect
The present invention relates to kojic acid-derived mannich base compounds with biological effect, and hydrates, solvates, pharmacologically acceptable salts or...
US-9,975,883 1,2-naphthoquinone based derivative and method of preparing the same
Disclosed are a compound represented by Formula (1), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, tautomer, enantiomer, or pharmaceutically...
US-9,975,882 Heteroaromatic compounds as BTK inhibitors
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the groups R.sub.1, Cy and Y are defined herein, which are suitable for the...
US-9,975,881 Compound
There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the...
US-9,975,880 Imidazolidine-2,4-dione dervatives
Imidazolidine-2,4-dione derivatives of formula (I): ##STR00001## These compounds have anti-proliferative activity and are useful for treating pathological...
US-9,975,879 Beta lactams as modulators of glutamate uptake and methods for use thereof
Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases...
US-9,975,878 Substituted triazine BMI-1 inhibitors
Amine substituted triazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus...
US-9,975,877 Benzimidazole-carboxamide compounds as 5-HT.sub.4 receptor agonists
The invention relates to benzimidazole-carboxamide 5-HT.sub.4 receptor agonist compounds of formula (I) ##STR00001## wherein R.sup.1 and X are as defined in...
US-9,975,876 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists
The present invention is directed to 2-pyridyloxy-3-ester-4-ether compounds which are antagonists of orexin receptors. The present invention is also directed to...
US-9,975,875 Diamide compounds having muscarinic receptor antagonist and Beta2 adrenergic receptor agonist activity
This invention relates to a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic...
US-9,975,874 Factor XIa inhibitors
The present invention provides a compound of Formula (I) (Formula (I)) and pharmaceutical compositions comprising one or more said compounds, and methods for...
US-9,975,873 Isoindoline derivatives
The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as...
US-9,975,872 Processes for the preparation of (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidin- ...
Provided are processes for the preparation of enantiomerically enriched or enantiomerically pure ...
US-9,975,871 Continuous arycyclic compound
This is to provide a continuous arycyclic compound having a DGAT1 inhibitory activity, and useful for prophylaxis and/or treatment of obesity or hyperlipidemia...
US-9,975,870 5,6-dimethoxy-1,1-dioxobenzo[b]thiophene-2-methyloxycarbonyl (DM-Bsmoc) and related amino-protecting groups
Amino acid protecting groups are provided for use in peptide synthesis. Particular compounds disclosed include 5,6-dimethoxy-1,1-dioxobenzo[b]thiophi...
US-9,975,869 Analogues of epicatechin and related polyphenols
The present invention provides novel analogs of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the...
US-9,975,868 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided...
US-9,975,867 Synthetic process for preparing 2-furoic acid derivatives
Disclosed herein are processes for forming 2-furoic acid derivatives represented by Formula (I): ##STR00001##
US-9,975,866 Process for synthesis of furan derivative using an acid catalyst and preparation thereof
In accordance with the present subject matter, there is provided a process for preparing a furan derivative, the process comprising the steps of contacting a...
US-9,975,865 Epoxidation process
A method for producing ethylene oxide comprising: a) providing one or more feed components, wherein the one or more feed components contains at least ethylene...
US-9,975,864 Preparation of cobicistat intermediates
The present disclosure provides crystalline piperidine sulfamoyl intermediates of formula 8 and 9. The present disclosure also relates to an improved process...
US-9,975,863 Modulators of sphingosine phosphate receptors
Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in...
US-9,975,861 Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer's disease
The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention...
US-9,975,860 Anti-angiogenic compounds
Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of...
US-9,975,859 Method for preparing nitrogen-containing aromatic compound by catalytic pyrolysis of organic material
Provided is a method for preparing a nitrogen-containing aromatic compound through catalytic pyrolysis from organic materials. The method comprises: feeding...
US-9,975,858 Benzimidazole derivatives and use thereof
The invention provides compounds that are useful as sodium channel blockers. In one aspect, the invention provides compounds of Formula I: ##STR00001## and...
US-9,975,857 Inhibition of bacterial biofilms with imidazole-phenyl derivatives
Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these...
US-9,975,856 Process for the preparation of (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-y- ...
Processes are described for the preparation of estrogen receptor modulating compound, ...
US-9,975,855 Pyrazole indanyl carboxamides
The present invention relates to novel 1-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these...
US-9,975,854 Benzomorphan analogs and use thereof
The invention provides compounds as represented by Formula I or I' and pharmaceutically acceptable salts, solvates, and diastereomers thereof: Wherein R.sup.1,...
US-9,975,853 Tetrahydroisoquinolinone derivatives and their use in the inhibition of the HSP70 protein
The present invention relates to tetrahydroisoquinolinone derivatives, a pharmaceutical composition comprising the same and the use of these derivatives in the...
US-9,975,852 Quinoline sulfonyl derivatives and uses thereof
The present disclosure relates to quinoline sulfonyl compounds, compositions comprising these compounds and their use, in particular for the treatment of...
US-9,975,851 Method for producing 2-acyliminopyridine derivative
A method for producing a compound represented by formula (I) comprises the steps of: acylating an amino group at position 2 of a compound represented by...
US-9,975,850 Process for the manufacture of idalopirdine via hydrogenation of an imine
The present invention relates to the preparation of N-(2-(6-fluoro-1H-indol-3-yl)-ethyl)-3-(2,2,3,3-tetrafluoropropoxy)-benzy- lamine (Compound I), INN-name...
US-9,975,849 Gossypol l-arginine schiff base compound with antitumor activities and a method of preparing the same
A compound with antitumor activities is represented by formula I: ##STR00001## A method of preparing the compound of formula I is also disclosed.
US-9,975,848 Inhibitors of HIV-1 entry and methods of use thereof
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal...
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