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Patent # Description
US-9,994,638 Peptide core-based multi-arm linkers for treating infectious diseases
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using...
US-9,994,637 Method of treating CD155 expressing cancers
The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is...
US-9,994,636 Anti-Siglec-15 antibodies and uses thereof
This disclosure relates to anti-Siglec-15 antibodies and uses thereof, in particular in the treatment of leukaemia, such as acute myeloid leukaemia.
US-9,994,635 Antagonists of IL-6 to raise albumin and/or lower CRP
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
US-9,994,634 Use of an IL-17/IL-23 bispecific antibody for treating inflammation
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include...
US-9,994,633 IP-10 antibodies and their uses
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of...
US-9,994,632 Humanized or affinity-matured anti Ang-2 antibody and uses thereof
An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with...
US-9,994,631 Signal biomarkers
Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefore.
US-9,994,630 Clostridium difficile antibodies
Compositions and methods for the treatment or prevention of Clostridium difficile infection in a subject are provided. The compositions comprise antibodies to...
US-9,994,629 Compositions and methods for generating a synthetic antibody
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a...
US-9,994,628 Peptides and combination of peptides for use in immunotherapy against various tumors
A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer,...
US-9,994,627 Methods for purifying erythropoietin analogs having lower isoelectric point
The present invention relates to a method for purifying an erythropoietin analog having a low isoelectric point below 4 by adding an N-linked sugar chain with...
US-9,994,626 Stable polypeptides binding to human complement C5
The invention relates to a polypeptide capable of binding human complement component 5 (C5), said polypeptide comprising the amino acid sequence ...
US-9,994,625 HSP104 variants and uses thereof
Protein misfolding underpins several fatal neurodegenerative disorders. The application is directed to recombinant Hsp104 proteins comprising missense mutations...
US-9,994,624 Filarial nematode vaccines, polypeptides, and nucleic acids
The present invention relates to vaccines comprising a ShK domain of a filarial nematode protein. These vaccines may be used for the prevention and/or treatment...
US-9,994,623 Entomotoxic polypeptides
The invention relates to novel entomotoxic polypeptides of the family of albumins 1b in legumes. Said polypeptides can be especially used as insecticides.
US-9,994,622 Expression system
Compositions and methods related to periplasmic expression of a toxin including diphtheria toxin or CRM197 are provided herein.
US-9,994,621 Genes encoding insecticidal proteins
The present invention relates to novel DNA sequences encoding insecticidal Cry1 C proteins derived from Bacillus thuringiensis, and their use in plants to...
US-9,994,619 Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and...
US-9,994,618 High efficiency method for purifying human papillomavirus virus-like particles
Provided is a method of purifying human papillomavirus (HPV) L1 proteins with high purity and high efficiency. According to the purification method, a...
US-9,994,617 Modulation of structured polypeptide specificity
The invention describes a method for selecting a polypeptide ligand having a desired level of specificity for a target, wherein the polypeptide ligand comprises...
US-9,994,616 c-Met protein agonist
A peptide functioning as a c-Met agonist is described. A peptide complex comprising two or more peptides that bind to a c-Met protein and a linker that links...
US-9,994,615 Self-regulated peptide hydrogel for insulin delivery
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided....
US-9,994,614 N-methyl-D-aspartate receptor modulators and methods of making and using same
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,994,613 Prodrug of an ICE inhibitor
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. ##STR00001## Compound I is useful for treating IL-1 mediated diseases such...
US-9,994,612 Refolding of recombinant proteins
Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the...
US-9,994,611 Chromatographic purification of antibodies from chromatin-deficient cell culture harvests
Methods for the improved purification of antibodies and other proteins from protein preparations including the steps of conditioning the protein preparation by...
US-9,994,610 Separation method for fucosylated antibodies
The present invention relates to a method for the separation of antibodies, specifically antibodies having different degrees of fucosylation. The method is...
US-9,994,609 Hydrophobic interaction protein chromatography under no-salt conditions
Various aspects and embodiments of the present disclosure relate to the purification antibodies by hydrophobic interaction chromatography under no-salt conditions.
US-9,994,608 Method for preparing substituted 3,7-dihydroxy steroids
The invention relates to processes for preparing 17-alkynyl-7-hydroxy-steroids, such as 17-Ethynyl-10R,13S-dimethyl ...
US-9,994,607 Compounds
A compound of Formula (I) ##STR00001## wherein Y.sup.1, Y.sup.2, X.sup.1, X.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.8, and R.sup.9...
US-9,994,606 Process for the purification of Rebaudioside A and compositions thereof
There is provided processes for the purification of rebaudioside A from Steviol glycoside compositions, such as Stevia extracts. Also provided are pure...
US-9,994,605 Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein
The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated...
US-9,994,604 Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them
The present invention relates to pyrazolotriazolyl nucleoside analogs, such as ##STR00001## oligonucleotide comprising them, and uses in treatment of...
US-9,994,603 Epimerisation of saccharides
The present invention relates to a process for an epimerization of a saccharide in a microdevice consisting of a network of micron-sized channels in presence of...
US-9,994,602 Spiroannulated nucleosides and process for the preparation thereof
We claim a simple strategy for the synthesis of a collection of C(3')-spirodihydroisobenzo-furannulated and C(3')-spirodihydroisobenzo-furannulated nucleosides...
US-9,994,601 Depolymerization of lignin using metal incorporated mesoporous silicate catalysts
Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid...
US-9,994,600 Prodrug compounds and uses therof
Provided herein are cyclic phosphorus-containing prodrug compounds, their preparation and their uses, such as treating diseases via modulating molecular targets...
US-9,994,599 Biaryl ligands
Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as "biaryl compound"), biaryl complexes, methods of making biaryl...
US-9,994,598 Polyene compound, preparation method and use thereof
Disclosed are a polyene compound, preparation method and use thereof. Provided in the present invention is the preparation method of a polyene compound I,...
US-9,994,597 Inorganic siloxane ladder composites and methods of their preparation
Inorganic siloxane ladder polymers with metal-aza/thio crown complexes, and methods of making and using such siloxane ladder polymers are disclosed. The...
US-9,994,596 Process for preparing a composition containing 2-ethylhexyl silicate
A composition containing 2-ethylhexyl silicate, is produced by heating a reaction mixture of ethyl silicate with an excess amount of 2-ethylhexanol in the...
US-9,994,595 Catalyst and battery components derived from condensation reactions with carba-closo-dodecaborate amines
Described herein is the fusion of two families of unique carbon-containing molecules that readily disregard the tendency of carbon to form four chemical bonds,...
US-9,994,594 Inhibitors of arginase and their therapeutic applications
Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-9,994,593 Copper compound, starting material for forming thin film, and method for manufacturing thin film
This invention provides a copper compound represented by General Formula (I) below. In General Formula (I), R.sup.1 to R.sup.3 independently represent a linear...
US-9,994,592 Anticancer activity of gold(III) complexes of meso-1,2-di(1-naphthyl)-1,2-diaminoethane
A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl.sub.2]Cl.2H.sub.2O (1) or...
US-9,994,591 Oxadiazolopyridine derivates for use as ghrelin O-acyl transferase (GOAT) inhibitors
The present invention relates to compounds of general formula I, ##STR00001## wherein the groups R.sup.1, R.sup.2 and n are defined as in claim 1, which have...
US-9,994,590 Substituted [1,2,4]triazolo[1,5-a]pyrazines as phosphodiesterase inhibitors
Provided herein are substituted [1,2,4]triazlolo[1,5-.alpha.]pyrazine compounds, and pharmaceutical compositions thereof, useful for the treatment of, for...
US-9,994,589 Compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy
Described herein are novel compounds and methods for the treatment and/or prevention of cerebral amyloidoses such as Alzheimer's disease (AD) and/or cerebral...
US-9,994,588 Crystal of imidazo-oxazine, pharmaceutical composition containing said crystal, and method for producing said...
An object of the present invention is to provide a crystal of trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]- ...
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