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Patent # Description
US-1,004,6065 Nucleic acid-encapsulating polymer micelle complex and method for producing same
A nucleic acid-encapsulating polymer micelle complex is formed of a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic...
US-1,004,6064 Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses
Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
US-1,004,6063 Benzodiazepines and conjugates thereof
Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for...
US-1,004,6062 Retractor
A retractor assembly comprising a spool configured to wind and unwind the webbing, a lock base, and an energy absorbing member having a first end operatively...
US-1,004,6061 Site-specific insulin conjugate
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an...
US-1,004,6060 Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the...
US-1,004,6059 Methods of administering an N-terminal modified PEG-TRAIL
Disclosed herein are an N-terminal modified PEG-TRAIL conjugates and methods of making and using thereof. The PEG-TAIL conjugates have bioactivity that is...
US-1,004,6058 Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
Examples may include a microsphere. The microsphere may include a biodegradable polymer. Furthermore, the microsphere may include a protein mixture selected...
US-1,004,6057 Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for...
There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization...
US-1,004,6056 Glycotargeting therapeutics
Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune...
US-1,004,6055 Bone targeted therapeutics and methods of making and using the same
The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such...
US-1,004,6054 PSMA binding ligand-linker conjugates and methods for using
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents....
US-1,004,6053 Protease triggered release of molecules from hydrogels
The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the...
US-1,004,6052 Method and formulation for cold treatment in adults and children with increased safety
Methods and dosage formulations for the safe treatment of cold, cough, flu, and sinus symptoms in children and adolescents by age and nature of symptoms, and...
US-1,004,6051 Drug carrier and method of using the same
A drug carrier and a method of using the same are provided, wherein the drug carrier includes a base made of a carbon fiber which is magnetic and has a first...
US-1,004,6049 Engineered cells expressing multiple immunomodulators and uses thereof
This invention relates to the field of therapeutics. Most specifically invention provides methods of generating in vitro engineered immune cells conditionally...
US-1,004,6048 Homogenous suspension of immunopotentiating compounds and uses thereof
The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating...
US-1,004,6047 Vector co-expressing vaccine and costimulatory molecules
Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among...
US-1,004,6046 Amino sphingoglycolipid analogues
The invention relates to amino sphingoglycolipid analogues and peptide derivatives thereof, compositions comprising these compounds and methods of treating or...
US-1,004,6045 Vaccine compositions and uses thereof
The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic...
US-1,004,6044 Prevention of pertussis using adenylate cyclase deficient Bordetella strains
A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination...
US-1,004,6043 GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly...
US-1,004,6042 Meningococcal conjugate vaccine for groups A, C, Y and W135 and a preparation method thereof
The present invention provides a meningococcal conjugate vaccine for groups A, C, Y and W135, which is a tetravalent conjugate vaccine comprising...
US-1,004,6041 Methods and compositions for suppressing virulence of methicillin resistant Staphylococcus aureus
The present invention is directed to methods of suppressing the virulence of one or more virulence antigenic factors of methicillin resistant Staphylococcus...
US-1,004,6040 Multivalent live vector vaccine against Clostridium difficile-associated disease
The invention relates to a multivalent Clostridium difficile vaccine comprising a Salmonella Typhi live vector comprising the cell binding domain of TcdA toxin...
US-1,004,6039 Bacterial vaccine and methods for manufacture thereof
Disclosed are stable conjugate vaccine formulations for protection against Salmonella typhi, and methods of conjugation between Vi-polysaccharide of S. typhi to...
US-1,004,6038 Leptospira with increased antigenic mass
The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a...
US-1,004,6037 Immunotherapy against several tumors including neuronal and brain tumors
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-1,004,6036 Chemically modified cystathionine .beta.-synthase enzyme for treatment of homocystinuria
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine .beta.-synthase (CBS) to...
US-1,004,6035 Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
US-1,004,6034 Hemostatic compositions
The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or...
US-1,004,6033 High concentration alpha-glucosidase compositions for the treatment of Pompe disease
The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for...
US-1,004,6032 Use of insulin for promoting gastric emptying
The present disclosure provides means and methods for promoting gastric emptying. In particular, the present disclosure provides the use of insulin or a...
US-1,004,6031 Use of ultrarapid acting insulin
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial...
US-1,004,6030 Compositions and methods for preventing and treating infection
The present invention encompasses compositions and methods useful to treat or prevent Clostridium difficile antibiotic-associated colitis through administration...
US-1,004,6029 Method of inducing senescence in tumor cells by administrating TNF-a in combination with IFNa or IFNy
The present invention relates to a combination of at least two different substances, one of which activates the STAT1-signalling cascade and the other of which...
US-1,004,6028 Methods and compositions for modulating PD1
Disclosed herein are methods and compositions for modulating expression of a PD1 gene.
US-1,004,6027 Muteins of tear lipocalin and methods for obtaining the same
The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding...
US-1,004,6026 Papillomavirus-like particles (VLP) as broad spectrum human papillomavirus (HPV) vaccines
This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human...
US-1,004,6025 Stabilizing alkylglycoside compositions and methods thereof
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity,...
US-1,004,6024 Cyclic-GluR6 analogs, methods of treatment and use
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising ##STR00001## wherein R is a molecular transporter with or...
US-1,004,6023 FC receptor (FcRn) binding peptides and uses thereof
The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin. Blocking...
US-1,004,6022 Synthetic peptide that increases radiosensitivity of tumor cells and use of same
Provided are a synthetic peptide that increases the radiosensitivity of tumor cells and a pharmaceutical composition containing that synthetic peptide. The...
US-1,004,6021 Phosphorylcholine conjugates and uses thereof
The present invention provides phosphorylcholine conjugates and pharmaceutical compositions comprising same for the prevention or treatment of autoimmune...
US-1,004,6020 Inflammation inhibiting compounds
The present invention relates to the use of compounds selected from the group consisting of Lys-(D)Pro-Thr, N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and...
US-1,004,6019 Purified extract (ATC1) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of...
The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as...
US-1,004,6018 Water-soluble phytocannabinoid formulations
Methods and formulations for increasing the water solubility and/or bioavailability of a phytocannabinoid compound is disclosed herein. In one example, a...
US-1,004,6017 Pomegranate skin extract for treating fatty liver
Use of a pomegranate skin extract for use in the treatment of metabolic syndrome, more particularly, fatty liver disease. More particularly, the pomegranate...
US-1,004,6016 Mutant adeno-associated virus virions and methods of use thereof
The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in...
US-1,004,6015 Compositions comprising bacterial strains
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
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