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Patent # Description
US-1,005,9695 Cot modulators and methods of use thereof
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
US-1,005,9694 2-aminopyrimidine compound and pharmaceutical composition and use thereof
Disclosed are a 2-aminopyrimidine compound and pharmaceutical composition and use thereof. The structure of the 2-aminopyrimidine compound is as represented by...
US-1,005,9693 Urea derivatives and uses thereof
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
US-1,005,9692 Urea derivatives and uses thereof
The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
US-1,005,9691 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor
The present invention relates to processes for preparing pyrazole derivatives of Formula (I) and salts and pharmaceutical compositions of the salts thereof,...
US-1,005,9690 Inhibitors of cyclin-dependent kinase 7 (CDK7)
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers,...
US-1,005,9689 Substituted heteroaryl compounds and methods of use
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, managing, treating or...
US-1,005,9688 Protein tyrosine kinase modulators and methods of use
Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More...
US-1,005,9687 Histone demethylase inhibitors
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
US-1,005,9686 Compound useful for manufacturing salacinol, method for manufacturing the compound, method for manufacturing...
An object of the present invention is to provide a novel compound useful for manufacturing salacinol, a method for manufacturing the compound, a method for...
US-1,005,9685 2-hydroxyethyl 2-oxo-1,3-dioxolane-4-carboxylates, their preparation and use
2-hydroxyethyl 2-oxo-1,3-dioxolane-4-carboxylates of formula (I): ##STR00001## wherein one of R.sub.1 and R.sub.2 can be hydrogen. R.sub.1 and R.sub.2, if not...
US-1,005,9684 Process to extract and purify .DELTA..sup.9-tetrahydrocannabinol
.DELTA..sup.9-THC acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. .DELTA..sup.9-THC acid...
US-1,005,9683 Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be...
US-1,005,9682 Asymmetric dianhyrdrides and methods of making the same
A method for preparing asymmetric 3,4'-(hexafluroisopropylidene) dipthalic anhydride (a-6FDA) and asymmetric 3,4'-(methylene)diphthalic anhydride (a-MDPA) from...
US-1,005,9681 Disubstituted maleic anhydrides with altered kinetics of ring closure
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible...
US-1,005,9680 Thiadiazolyl-oximinoacetic acid derivative compounds
Thiadiazolyl-oximinoacetic acid derivatives have been synthesized, which are useful in the manufacture of cephalosporin antibiotic compounds. Compound (1)...
US-1,005,9679 Method for producing polymerizable compound
Provided is a method for producing a polymerizable compound represented by a formula (I) comprising: a step (1) that reacts a compound represented by a...
US-1,005,9678 Process for preparing olodaterol and intermediates thereof
The present invention relates to a process for preparing olodaterol and intermediates thereof. The process comprises of forming compound of Formula 1 by...
US-1,005,9677 Process for preparing phosphatidylinositol 3-kinase inhibitors and intermediates thereof
A process for the synthesis of benzoxazinone containing compounds which may be useful precursors for synthesizing compounds for the treatment of cancer, is...
US-1,005,9676 Process for preparing a novel crystalline form of iodosulfuron-methyl-sodium and use of the same
A crystalline form of iodosulfuron-methyl-sodium of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods...
US-1,005,9675 Pyrimidines as sodium channel blockers
The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof,...
US-1,005,9674 Design, synthesis, and biological evaluation of 1-methyl-1, 4-dihyrdoindeno[1,2-C]pyrazole analogues as...
The invention discloses an indenopyrazole small-molecule tubulin inhibitor, which is characterized by having a structure represented by general formula I: ...
US-1,005,9673 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene
A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) as described herein and further reactions with this compound.
US-1,005,9672 (-)-Huperzine A processes and related compositions and methods of treatment
The invention provides (1) processes for making substantially-pure (-) huperzine A and substantially-pure (-) huperzine A derivatives; (2) compositions useful...
US-1,005,9671 Positive allosteric modulators of mGluR3
The present invention relates to novel substituted pyridine derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype...
US-1,005,9670 Synthesis of 2-carboxamide cycloamino urea derivatives
Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates...
US-1,005,9669 2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treating...
The present invention is directed to compounds according to Formula (I) which compounds are inhibitors of the BACE1 enzyme. Separate aspects of the invention...
US-1,005,9668 LSD1 inhibitors
The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions...
US-1,005,9667 Antidiabetic compounds
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
US-1,005,9666 Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
The disclosure relates to oxygen scavenging molecules, compositions, methods of making the compositions, articles prepared from the compositions, and methods of...
US-1,005,9664 Sepiapterin reductase inhibitors for the treatment of pain
Disclosed herein are small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and prodrugs and pharmaceutically acceptable salts thereof. The Also...
US-1,005,9663 Aromatic compound and use thereof
Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a ...
US-1,005,9662 Sulfonium salt, photoacid generator, and photosensitive composition
A novel sulfonium salt having high sensitivity with respect to active energy rays, a photoacid generator including the sulfonium salt, and a photosensitive...
US-1,005,9661 Method of fabricating [F-18]FEONM precursor
A [F-18]FEONM precursor is synthesized. 2-bromoethanol is added to further connect an atom of oxygen at an N terminal of the precursor. Four atoms of carbon can...
US-1,005,9660 Solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopen- ...
A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopen- tyl)methyl)urea hydrochloride (also referred to "ATR-101")...
US-1,005,9659 Enantiomerically pure binaphthol derivatives and method for preparing the same
The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula...
US-1,005,9658 Method for preparation of 5-alkylsalicylaldoximes and application thereof
Method for preparation of 5-alkylsalicylaldoximes with formula 1, where R is a C6-C16 alkyl group, consisting in that into a water-alcohol solvent system,...
US-1,005,9657 Class-and isoform-specific HDAC inhibitors and uses thereof
HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone...
US-1,005,9656 Catalyst composition for polymerization of olefins
A catalyst composition including the compound of Formula I as an internal electron donor, ##STR00001## wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5...
US-1,005,9655 Lipids and lipid compositions for the delivery of active agents
This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R.sup.1-R.sup.4, n and p are defined herein. The...
US-1,005,9654 Composition containing 3-chloro-4-methoxybenzylamine hydrochloride, and method for producing same
There is provided a method for producing, at a high yield, a composition containing 3-chloro-4-methoxybenzylamine hydrochloride (CMBA-HCl) in which the purity...
US-1,005,9653 Process for the preparation of indanamine derivatives and new synthesis intermediates
Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also...
US-1,005,9652 Heterogeneous catalysts for the transesterification of aromatic alcohols; and methods of making and use thereof
Disclosed herein are new mixed metal oxide catalysts suitable as heterogeneous catalysts for catalyzing the transesterification process of aromatic alcohols...
US-1,005,9651 Separation process
The azeotrope, or near azeotrope, of methanol and MMA is separated via extractive distillation using an extractive distillation solvent comprising cyclohexanone.
US-1,005,9650 Systems and methods for the depolymerization of a biopolymer
Methods for the production and isolation of a monomer from a biopolymer are described. The method includes extracting a biopolymer from a biopolymer source and...
US-1,005,9649 Method for producing ethanol and coproducing methanol
A method for producing ethanol and coproducing methanol on a catalyst in a reactor using a co-feed of a synthesis gas and acetate as a reaction raw material...
US-1,005,9648 Method for producing fluorine-containing compounds
Provided is an efficient method for producing a fluorine-containing compound without the need for a rectification column involving numerous stages, extractive...
US-1,005,9647 Method for producing fluorinated organic compounds
Disclosed are processes for the production of fluorinated olefins, preferably adapted to commercialization of CF.sub.3CF.dbd.CH.sub.2 (1234yf). Three steps may...
US-1,005,9646 Catalytic gas phase fluorination
The present invention relates to a fluorination process, comprising: an activation stage comprising contacting a fluorination catalyst with an oxidizing...
US-1,005,9645 Systems and methods for producing propylene
According to one embodiment described in this disclosure, a process for producing propylene may comprise at least partially metathesizing a first stream...
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