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Patent # Description
US-1,007,7293 Antimicrobial peptide analogues derived from abalone (Haliotis discus) and antimicrobial pharmaceutical...
The present disclosure relates to an antimicrobial peptide analog derived from abalone and an antimicrobial pharmaceutical composition containing the same. The...
US-1,007,7292 Formaldehyde-free proteinaceous binder compositions
Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second...
US-1,007,7291 Methods and compositions for dual glycan binding AAV vectors
The present invention provides methods and compositions comprising an adeno-associated virus (AAV) capsid protein, comprising one or more amino acids...
US-1,007,7290 Stabilized antiviral fusion helices
Internally cross-linked peptides useful for interfering with Respiratory Syncytial Virus (RSV) infection is based on RSV-F protein. These peptides are capable...
US-1,007,7289 Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using...
US-1,007,7288 Hydroxystatin derivatives for the treatment of arthrosis
The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula (I) for use in...
US-1,007,7287 Tubulysin analogs and methods of making and use
Tubulysin analogs of the formula (I) ##STR00001## where R.sup.1, R.sup.2 R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and Y are as defined herein, are...
US-1,007,7286 Method for removal of triglycerides in lipoproteins other than low-density lipoproteins
Disclosed is a method for selectively eliminating triglycerides in lipoproteins other than low density lipoprotein, which method allows one to provide a method...
US-1,007,7285 Enhanced functionality and delivery of a protein from a porous substrate
Compositions, methods, articles of manufacture, and kits are provided for storage and delivery of proteins.
US-1,007,7284 UBA5 inhibitors
The present disclosure relates to compounds of the Formula (I), which are UBA5 inhibitors.
US-1,007,7283 Process for fractionating lignocellulosics
A method for the isolation of lignin from a lignocellulosic biomass, comprising providing a lignocellulosic biomass; extracting sugar free lignin from the...
US-1,007,7282 Raw material for chemical deposition composed of organoplatinum compound, and chemical deposition method using...
The present invention relates to a raw material for chemical deposition shown in a formulae below and including an organoplatinum compound in which diimine...
US-1,007,7281 Crystalline ligand
A ligand crystal structure of 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bi- s(oxy)]bisdibenzo[d,f][1,3,2]-dioxaphosphepin. Formule...
US-1,007,7280 Mixed ligand gold(I) complexes as anti-cancer agents
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
US-1,007,7279 Vinylsilanes for use in functionalized elastomeric polymers
The present invention relates to novel vinylsilane compounds which are useful as modifying monomers in the polymerization of conjugated diene monomers,...
US-1,007,7278 Synthetic methods for diboron reagents and related compounds
The disclosure is directed to diboron compounds, related methods of making, and related intermediate boron and diboron compounds used to make the same. The...
US-1,007,7277 Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
This application relates to derivatives of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and...
US-1,007,7276 N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
The present invention relates to compounds of formula I: ##STR00001## in which p, q, Y.sub.1, Y.sub.2, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
US-1,007,7275 Process for production of a spiroglycol
Disclosed is a process for production of a spiroglycol by subjecting pentaerythritol to reaction in water with hydroxypivaldehyde in presence of a catalytically...
US-1,007,7274 UV-curing-compatible photochromic fused naphthopyrans
The present invention relates to UV-curing-compatible photochromic single- or double-fused naphthopyrans of the general formulae (I) or (II) and the use thereof...
US-1,007,7273 SHMT inhibitors
The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have...
US-1,007,7272 Heteroaromatic compounds and their use as dopamine D1 ligands
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
US-1,007,7271 Methods and compositions for inhibiting the interaction of menin with MLL proteins
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The...
US-1,007,7270 HIV inhibiting bicyclic pyrimidine derivatives
HIV replication inhibitors of formula ##STR00001## wherein -a.sup.1=a.sup.2-a.sup.3=a.sup.4- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--,...
US-1,007,7269 Imidazopyridazine compounds
The present invention is directed to compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the substituents R.sup.1,...
US-1,007,7268 FXR agonists and methods for making and using
Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are...
US-1,007,7267 Organic compounds
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or...
US-1,007,7266 Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
The present invention provides compounds of formula I: ##STR00001## which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for...
US-1,007,7265 Substituted oxopyridine derivatives
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments...
US-1,007,7264 Derivatives and methods of treating hepatitis B infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
US-1,007,7263 Process for the preparation of Apixaban
The present invention relates to an improved process for the preparation of Apixaban and its intermediates.
US-1,007,7262 Thienothiadiazole compounds and related semiconductor devices
The present invention relates to new semiconducting compounds having at least one optionally substituted thienothiadiazole moiety. The compounds disclosed...
US-1,007,7261 Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of...
US-1,007,7260 Read-through compound prodrugs suppressing premature nonsense mutations
Premature termination codon readthrough prodrug compounds, compositions thereof, and methods of making and using the same are provided. In certain embodiments,...
US-1,007,7259 Bicyclic heterocyclic derivatives as bromodomain inhibitors
The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain...
US-1,007,7258 Substituted pyrimidine compounds as phosphatidylinositol 3-kinase delta inhibitor and use thereof
The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K)...
US-1,007,7257 Aziridinated triglycerides and polymers formed therefrom
Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an...
US-1,007,7256 Synthetic route to anti-viral agents
The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
US-1,007,7255 Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones
The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its...
US-1,007,7254 Tetrazolinone compound and use thereof
A tetrazolinone compound represented by formula (1) ##STR00001## wherein E represents the following group E16; ##STR00002## Y represents --O--CH.sub.2--;...
US-1,007,7251 Process for the synthesis of Dabigatran Etexilate and its intermediates
The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the...
US-1,007,7250 Antifungal compound process
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new...
US-1,007,7249 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzal- dehyde
Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzal- dehyde (also referred to herein as...
US-1,007,7248 Form of imazapyr, a process for its preparation and use the same
The present invention describes the crystalline form of imazapyr of formula (I), the crystal preparation process, the analyses of the crystal through various...
US-1,007,7247 Tricyclic spiro compound
A medicinal agent for the prevention and/or treatment of diseases caused by EP.sub.4 receptor activation. A compound having antagonistic activity against the...
US-1,007,7246 Tricyclic prodrugs
Prodrugs (I) and (Ia) of galiellactone, and derivatives thereof, are provided by reacting the parent compound, e.g. galiellactone, with a thiol. Such drugs may...
US-1,007,7245 KCNQ potassium channel agonists, method of preparation and method of use thereof
The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the...
US-1,007,7244 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
A method to detect the presence of amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is...
US-1,007,7243 Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
Provided herein are compounds of formula (I): ##STR00001## and pharmaceutical compositions thereof, useful for the treatment of disorders mediated by...
US-1,007,7242 Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two...
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