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| Patent # | Description |
|---|---|
| US-1,010,0128 |
Monoclonal anti-TK1 antibodies Monoclonal antibodies and fragments thereof are capable of binding to a serum form of human TK1. Kits and methods involve the use of such monoclonal antibodies... |
| US-1,010,0127 |
Passive immunization for Staphylococcus infections Disclosed herein are monoclonal antibodies or binding portion thereof that bind specifically to a Staphylococcus spp. autolysin N-acetylmuramoyl-L-alanine... |
| US-1,010,0126 |
Antibody therapeutics that bind PSMA There is disclosed compositions and methods relating to or derived from anti-PSMA antibodies. More specifically, there is disclosed fully human antibodies that... |
| US-1,010,0125 |
Humanised anti kallikrein-2 antibody The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a... |
| US-1,010,0124 |
Antibodies directed to HER-3 and uses thereof The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the... |
| US-1,010,0123 |
Anti-C10orf54 antibodies and uses thereof The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use. |
| US-1,010,0121 |
Anti-mesothelin binding proteins The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which... |
| US-1,010,0120 |
Antibody which specifically binds to human CRTH2 There is provided an anti-human CRTH2 antibody which has desired activity by recognizing and binding to a specific human CRTH2; the antibody fragment; DNA which... |
| US-1,010,0119 |
Anti-human interleukin-1 receptor accessory protein antibody and its use
for treating cancer The present invention provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein... |
| US-1,010,0118 |
Antibody therapeutics that bind CD123 There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies. More specifically, there is disclosed fully human antibodies that... |
| US-1,010,0117 |
Insulin-like growth factor 1 receptor-specific antibodies and uses thereof The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates... |
| US-1,010,0116 |
Fc.gamma.RIIB-specific antibodies and methods of use thereof The present invention relates to antibodies or fragments thereof that specifically bind Fc.gamma.RIIB, particularly human Fc.gamma.RIIB, with greater affinity... |
| US-1,010,0115 |
Methods for the treatment of vascularizing cancers The invention concerns therapeutic compositions for the treatment of vascularizing cancers, especially, glioblastoma. In particular, the invention is directed... |
| US-1,010,0114 |
Antibodies specific for TROP-2 and their uses The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody... |
| US-1,010,0113 |
Maternal TH17 cells and psychiatric disorders Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an... |
| US-1,010,0112 |
Therapeutic agents for the treatment of diseases associated with undesired
cell proliferation The present invention relates to inhibitors of the expression and/or activity of LIF for the treatment of cancer. Particularly, the present invention provides... |
| US-1,010,0111 |
Stable and soluble antibodies inhibiting TNF alpha The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and... |
| US-1,010,0110 |
Sequences directed against hepatocyte growth factor (HGF) and polypeptides
comprising the same for the... The present invention relates to biological materials against HGF and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods... |
| US-1,010,0109 |
Anti-activin A antibodies and uses thereof The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments,... |
| US-1,010,0108 |
Antibodies to HGF and compositions containing The present invention is directed to antibodies and fragments thereof having binding specificity for HGF. Another embodiment of this invention relates to the... |
| US-1,010,0107 |
Method for identifying a compound useful with myosin regulatory light
chain polypeptide antibody for treatment... Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for... |
| US-1,010,0106 |
Single domain serum albumin binding protein Disclosed herein are single domain serum albumins binding proteins with improved thermal stability, binding affinities, and robust aggregation profiles. Also... |
| US-1,010,0105 |
Anti-polyubiquitin antibodies and methods of use The invention provides anti-polyubiquitin antibodies and methods of using the same. |
| US-1,010,0104 |
Methods of diagnosing tau-protein-associated disease The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by... |
| US-1,010,0103 |
Opsonic and protective monoclonal antibodies against gram-positive
pathogens The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive... |
| US-1,010,0102 |
Compositions and methods for inhibiting pathogen infection The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating pathogen infection and providing... |
| US-1,010,0101 |
Compositions and methods related to viral vaccines Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof. |
| US-1,010,0100 |
Metallothionein-derived peptide fragments The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT),... |
| US-1,010,0099 |
Method of producing recombinant high molecular weight vWF in cell culture Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a... |
| US-1,010,0098 |
Insulin production methods and proinsulin constructs Novel proinsulins and glargine, aspart and Lis-Pro proinsulin analogs having specific amino acid and/or nucleic acid modifications suitable for improved methods... |
| US-1,010,0097 |
GIP-GLP-1 dual agonist compounds and methods The present invention relates to truncated GIP analogs which comprise one or more substitutions as compared to wild-type GIP and which may have the property of... |
| US-1,010,0096 |
Tissue protective peptides and uses thereof The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor... |
| US-1,010,0095 |
Resistant mutant 90 kDa heat shock protein An object to be solved by the present invention is to identify patients resistant to known HSP90 inhibitors, and to provide a novel therapeutic agent for... |
| US-1,010,0094 |
Fusion proteins, cells, and kits for characterizing Botulinum toxin Compositions for characterization of Botulinum toxin (BoNT) are described that include a genetically modified cell that is transfected with an artificial... |
| US-1,010,0093 |
Polypeptides and immunizing compositions containing Burkholderia
polypeptides and methods of use This disclosure provides isolated polypeptides isolatable from a Burkholderia spp., compositions that include one or more of the polypeptides, and methods for... |
| US-1,010,0092 |
Compositions and methods to detect various infectious organisms The invention relates to compositions and methods for the detection of various infectious organisms, including heartworm (Dirofilaria immitis), Ehrlichia Canis,... |
| US-1,010,0091 |
Fusion protein for HIV-1 gp120 antigen detection The present disclosure relates to novel fusion proteins that bind to the HIV-1 gp120 antigen. The present disclosure also relates to nucleic acids, plasmids and... |
| US-1,010,0090 |
Substituted urea depsipeptide analogs as activators of the CLPP
endopeptidase In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with... |
| US-1,010,0089 |
Process for the preparation of cyclic depsipeptides Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R.sub.1-R.sub.7, L and n are defined herein. Intermediates... |
| US-1,010,0088 |
Glycopeptide derivatives for the preservation and protection of biological
materials and microorganisms The present invention relates to a compound of the following formula (I): ##STR00001## in which at least one and only one group chosen among R.sup.5, R.sup.6... |
| US-1,010,0087 |
Immunogenic WT-1 peptides and methods of use thereof This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a... |
| US-1,010,0086 |
Peptide and uses thereof This present invention provides a novel peptide for inhibiting growth of microorganisms, a pharmaceutical composition, an antimicrobial composition comprising... |
| US-1,010,0085 |
Immunotherapy against several tumors including neuronal and brain tumors The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the... |
| US-1,010,0084 |
Template-fixed beta-hairpin peptidomimetics with protease inhibitory
activity Template-fixed .beta.-hairpin peptidomimetics of the general formulae ##STR00001## wherein Z is a chain of 11 .alpha.-amino acid residues which, depending on... |
| US-1,010,0083 |
Leukemia stem cell targeting ligands and methods of use The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of... |
| US-1,010,0082 |
Hexapeptide for neuroprotection against a .beta. toxicity The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This... |
| US-1,010,0081 |
Trapping reagents for reactive metabolites screening The present invention provides compounds of Formula (I) and (II): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, X and n are as defined... |
| US-1,010,0080 |
Split inteins and uses thereof The present invention relates generally to robust split inteins. The split inteins described herein are active over a large temperature range, including... |
| US-1,010,0079 |
Progesterone-cationic lipid hybrid as anticancer agent and the process of
synthesis thereof The present invention relates to the development of the cationic progesterone compounds as a novel anti-tumor agent. The present invention provides a method for... |
| US-1,010,0078 |
Nanoparticles, process for preparation and use thereof as carrier for
amphipatic and hydrophobic molecules in... The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja... |
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