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Patent # Description
US-1,010,0077 6-aryl-9-glycosylpurines and use thereof
6-aryl-9-glycosidpurines of general formula I ##STR00001## and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition...
US-1,010,0076 Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation
The disclosed invention is a composition for and a method of seating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or...
US-1,010,0075 Process for the preparation of sofosbuvir
The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides...
US-1,010,0074 Regioselective silyl exchange of per-silylated oligosaccharides
The present invention provides novel, regioselectively-acylated oligosaccharide compounds and methods for preparing them. In another aspect, the. invention...
US-1,010,0073 Method for preparing low-molecular lignin derivative
A method of preparing a low-molecular lignin derivative comprises the step of: preparing lignin by hydrolyzing lignocellulosic biomass with an acid; preparing a...
US-1,010,0072 Phosphonate compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,010,0071 Heterocyclic selenamonophosphites protected on a hydroxyl group and processes for preparation thereof
Novel heterocyclic selenamonophosphites protected on the hydroxyl group, processes for preparation thereof and the use thereof as ligand.
US-1,010,0070 Borate-based base generator, and base-reactive composition comprising such base generator
A compound capable of providing a composition having high storage stability without reacting with a base-reactive compound, even when stored in a mixed state...
US-1,010,0069 Rapid-curing, migration-free composition based on organic polymers containing silane groups
The invention relates to a composition comprising at least one organic polymer that contains silane groups and at least one catalyst of formula (I). The...
US-1,010,0068 Amidine group--or guanidine group--containing silane
A silane of the formula (I) containing at least one aliphatic amidine group- or guanidine group-containing alkoxy group, to a method for producing same, to...
US-1,010,0067 Method for producing cyanoalkyl fluorosilanes
Cyanoalkylfluorosilanes are prepared in exceptionally high yield by the reaction of the corresponding cyanoalkylchlorosilanes with specific metal fluorides. The...
US-1,010,0066 Modulators of sestrin-GATOR2 interaction and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
US-1,010,0065 Compound for labeling mitochondria and method of producing the same
This invention relates to a compound for labeling mitochondria and a method of producing the same, wherein the compound is represented by Chemical Formula 1 or...
US-1,010,0064 Purine inhibitors of human phosphatidylinositol 3-kinase delta
The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated...
US-1,010,0063 Compounds that inhibit Mcl-1 protein
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using...
US-1,010,0062 Methods for the acylation of maytansinol
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence...
US-1,010,0061 Oxazepine compound and agricultural/horticultural insecticide containing said compound as active ingredient,...
An oxazepine compound, or salt thereof, has General Formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be identical or different,...
US-1,010,0060 Asymmetric synthesis of funapide
This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or...
US-1,010,0059 Apelin receptor (APJ) agonists and uses thereof
This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
US-1,010,0058 Fused heterocyclic compounds as CaM kinase inhibitors
The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial...
US-1,010,0057 Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising...
US-1,010,0056 SHIP1 modulators and methods related thereto
Compounds of formula (I): where R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6 and R.sup.7 are defined herein, or stereoisomers or...
US-1,010,0055 Imidazopyrroloquinoline salt, method for producing the same, medicament, cosmetic, and food
There is provided a production method for the purpose of improving the solubility of an arginine-residue imidazopyrroloquinoline in water and making the purity...
US-1,010,0054 Pyrido[2,3-d]pyrimidines as anticancer agents
The pyrido[2,3-d]pyrimidine derivatives as anticancer agents include 5-(substituted-phenyl)-2-(3-methyl-5-oxo-2H-pyrazol-1(5H)-yl)-7-(pyridin-- ...
US-1,010,0053 Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-b]pyrazin-3-one derivatives
The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of ...
US-1,010,0052 Compounds for the treatment of hepatitis B virus infection
The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
US-1,010,0051 Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof...
A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided....
US-1,010,0050 Kinase inhibitors
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
US-1,010,0049 JAK kinase inhibitor compounds for treatment of respiratory disease
The invention provides compounds of formula (I): ##STR00001## wherein X is ##STR00002## and the variables are defined in the specification, or a...
US-1,010,0048 Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the...
US-1,010,0047 Piperidine derivatives as orexin receptor antagonist
The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application...
US-1,010,0046 Inhibitors of lysine specific demethylase-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
US-1,010,0045 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, ##STR00001## Also provided herein are...
US-1,010,0044 Methods for preparing brexpiprazole, key intermediates thereof and salts thereof
The present invention relates to the methods for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, specifically, the present invention...
US-1,010,0043 Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
Provided are cycloalkyl- and cycloalkenyl-substituted benzaldehydes and heteroaldehydes of formula (I) that act as allosteric modulators of hemoglobin, methods...
US-1,010,0042 [5,6]--fused bicyclic antidiabetic compounds
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
US-1,010,0041 Pyrazolyl substituted tetrahydropyranylsulfones
The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing...
US-1,010,0040 Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
US-1,010,0039 Allisartan isoproxil polymorph, its preparation method and pharmaceutical
Disclosed are polymorph of allisartan isoproxil and a pharmaceutical composition thereof. The polymorph is non-electrostatic, highly flowable and highly stable,...
US-1,010,0038 Isoquinolin-3-yl carboxamides and preparation and use thereof
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline...
US-1,010,0037 Activity-based probe compounds, compositions, and methods of use
Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting...
US-1,010,0036 Lappaconitine aza-cinnamic acid derivatives with anti-tumor activities and a method of preparing the same
A lappaconitine aza-cinnamic acid derivative having the following formula (I): ##STR00001## X is C or N, and R.sub.1, R.sub.2, and R.sub.3 are independently H...
US-1,010,0035 Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and...
The present invention relates to certain intermediates useful in the preparation of certain benzoimidazol-2-yl pyrimidines and processes for preparing them. In...
US-1,010,0034 Process for preparing an anti-cancer agent, ...
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine...
US-1,010,0033 Processes for the preparation of pesticidal compounds
This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers and pesticidal sulfoxides....
US-1,010,0032 Crystalline forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
The invention relates to novel crystalline forms of 3-(4-amino-l-oxo-l,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione, including a novel urea cocrystal of...
US-1,010,0031 Manufacturing process for triazine, pyrimidine and pyridine derivatives
The invention relates to a method of manufacturing triazine, pyrimidine and pyridine derivatives of formula (I), wherein U, V, W and Z are nitrogen or carbon...
US-1,010,0030 Carboxymethyl piperidine derivative
The present invention provides a new compound which has NK.sub.1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to...
US-1,010,0029 Combretastatin analogs
The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of...
US-1,010,0028 Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis
Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal-catalyzed...
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