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Patent # Description
US-1,011,1968 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal...
The present invention relates to a nucleic add sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a...
US-1,011,1967 Complexes of RNA and cationic peptides for transfection and for immunostimulation
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
US-1,011,1966 Methods for the depletion of CD117+ cells
The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic...
US-1,011,1965 Cell penetrating peptides for intracellular delivery of molecules
A cell-penetrating peptide characterized in that it comprises an amino acid sequence X.sub.3X.sub.4X.sub.1X.sub.2X.sub.5X.sub.4X.sub.1X.sub.2X.sub.6X.sub.7X.s- ...
US-1,011,1964 Compounds and compositions for the treatment of ocular disorders
The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and...
US-1,011,1963 Nanoparticle drug conjugates
Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based...
US-1,011,1962 Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
Provided herein are peptide-linked morpholino (PPMO) antisense oligonucleotides that target the poly CUG repeat tract in the 3' untranslated region of the gene...
US-1,011,1961 Self-associating microparticles and nanoparticles consisting of proteins
Microparticles and nanoparticles of hydrophobized proteins and an alpha-cyclodextrin, obtained by auto-association in an aqueous medium, the hydrophobized...
US-1,011,1960 9-OH-risperidone controlled release composition
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The...
US-1,011,1959 Antimicrobial gels
The present invention pertains to antimicrobial compositions comprising inter alia at least one alkenyl- and/or alkynyl-substituted polysiloxane, at least one...
US-1,011,1958 Anti-CD40 antibody formulation
Anti-CD40 antibodies are formulated as lyophilizate or liquid formulation. The lyophilizates can be reconstituted to give a solution with a high concentration...
US-1,011,1957 Inhalation compositions comprising glucose anhydrous
The invention relates to pharmaceutical powder compositions administered by means of inhalers. More particularly, it relates to pharmaceutical powder...
US-1,011,1956 Corticosteroid compositions
The present disclosure generally relates to pharmaceutical corticosteroid compositions, and methods of making the same.
US-1,011,1955 PEG derivative
Provided is a new therapeutic agent for a malignant tumor, which is highly safe, sustains an antitumor effect, and can improve the means for administration and...
US-1,011,1954 Combination therapy for inducing immune response to disease
The present invention concerns combinations of two or more agents for inducing an immune response to cancer or infectious disease. Agents may include leukocyte...
US-1,011,1953 Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of...
The present invention provides methods for reducing various lipoprotein fractions in the serum of patients. The methods of the invention include reducing serum...
US-1,011,1952 Silicon dioxide nanoparticles and the use thereof for vaccination
The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The...
US-1,011,1951 Human iNKT cell activation using glycolipids with altered glycosyl groups
Glycosphingolipids (GSLs) bearing .alpha.-glucose (.alpha.-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with...
US-1,011,1950 Modified glycolipids and methods of making and using the same
The invention is directed to compositions and methods related to proteins that are physically associated with ceramide-like glycolipids for use as activators of...
US-1,011,1948 Synthetic hapten carrier compositions and methods
The present disclosure relates to peptide monomers comprising an amphipathic ?-helical peptide, and optionally, at least one T cell epitope peptide; and to...
US-1,011,1947 Virus-containing formulation and use thereof
The present invention relates to formulation comprising (i) at least one virus-based material, (ii) at least one polymer selected in the group of ...
US-1,011,1946 Poxviral vectors for low antibody response after a first priming immunization
The invention is drawn to compositions and methods for the induction of an immune response, in particular a strong CD8 T cell response, to a specific antigenic...
US-1,011,1945 CMV vaccines
Provided herein are genetically modified arenaviral vectors suitable as vaccines for prevention and treatment of cytomegalovirus infections and reactivation....
US-1,011,1944 Influenza virus vaccines and uses thereof
Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the...
US-1,011,1943 Alphavirus replicon particles matched to protein antigens as immunological adjuvants
The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an...
US-1,011,1942 Targets of Acinetobacter baumannii
The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising...
US-1,011,1941 Method for treating Stage IV melanoma
The present invention relates to a method of treating Stage IV melanoma in a subject. The method includes the step of administering to the subject a...
US-1,011,1940 Prostate cancer vaccine
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in...
US-1,011,1939 Albumin-free botulinum toxin formulations
This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to...
US-1,011,1938 Injection paradigm for administration of botulinum toxins
Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a...
US-1,011,1937 Method of reducing accumulation of intracellular tingible body macrophages
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More...
US-1,011,1936 Metal-glycoprotein complexes and photodynamic therapy of immune privileged sites with same
Compositions of the invention include glycoproteins, such as transferrin, and metal-based coordination complexes, which are preferably chemotherapeutic...
US-1,011,1935 Agent for capturing tumor cells and methods of use thereof
The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention...
US-1,011,1934 IGF-1 proteins and therapeutic uses thereof
The present disclosure provides for techniques using pro-IGF-I for increasing IGF-I activity. Accordingly, the present disclosure provides for compositions and...
US-1,011,1933 Use of growth hormone fragments
The invention provides a method for treating a condition in which growth hormone administration is beneficial, for treating osteoarthritis, for increasing...
US-1,011,1932 Coagonists of glucagon-like peptide 1 receptor and neuropeptide Y2 receptor
Peptide sequences that can serve as agonists of both the glucagon-like peptide 1 receptor (GLP-IR) and the neuropeptide Y2 receptor (NPYR2). The peptide...
US-1,011,1929 Growth hormone releasing factor analogs and uses
Growth hormone releasing factor (GHRF) analogs that can be used to induce endogenous growth hormone secretion are disclosed, as well as pharmaceutical...
US-1,011,1928 Pulsed introduction of low-dose RANKL as a therapy for osteogenesis imperfecta
Systems and methods for treating osteogenesis imperfecta using FoxP3+ CD8 T-cells (Tc.sub.REG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells...
US-1,011,1927 Pseudomonas exotoxin A with less immunogenic B cell epitopes
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more of amino acid residues E420, D463,...
US-1,011,1926 Selectively targeted antimicrobial peptides and the use thereof
The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial...
US-1,011,1925 Formulations comprising plant extracts
The present invention is related to a formulation comprising Hedera helix, Pelargonium sidoides, and Zingiber officinale extracts to be used in the treatment,...
US-1,011,1924 Dietary supplement for the treatment of acid reflux and gastro-oesophageal reflux disease (GORD/GERD)
Use of dietary fiber material extracted from sugar cane in the manufacture of a food product that is formulated to ameliorate the effects of acid reflux and...
US-1,011,1923 Compositions comprising Cyclocarya paliurus extract and preparation method and uses thereof
Compositions and preparation method thereof, said compositions comprise herb extract from a mixture comprising Cyclocarya paliurus leaf and one or two herbs...
US-1,011,1922 Preparation method of tea water, and tea water obtained thereby
The present invention provides a preparation method of tea water comprising the following steps of: inactivating enzymes of raw tea leaves and juicing the tea...
US-1,011,1921 Regulation of brain biogenic amines associated with depression by a formulation from botanical source
Provided herein are anti depressant and anxiolytic herbal formulations including: 225-450 mg of Nyctanthes arbor-tristis, 250-550 mg Ocimum tenuiflorum, 200-450...
US-1,011,1920 Salt-free miso production method, salt-free miso, hepatic function improvement agent, and hypertension...
Provided are: a production method for salt-free miso, in which steamed soy beans and koji are pressurized, heated, and fermented; salt-free miso obtained by...
US-1,011,1919 Cosmetic compositions
Disclosed is a method for treating pruritus comprising topically applying a composition that includes effective amounts of an extract from Echinacea purpurea...
US-1,011,1918 Method of preparing biologically active derivatives from Calotropis gigantea flowers
A method of preparing biologically active derivatives from Calotropis gigantea flowers includes obtaining fresh Calotropis gigantea flowers, drying the flesh...
US-1,011,1917 Method for preparing purified extracts of harpagophytum procumbens
A method for preparing a concentrated extract of Harpagophytum procumbens, in liquid or dry form, having a harpagoside titer greater than or equal to 5%,...
US-1,011,1916 Compositions comprising Bacillus coagulans spores and whey
The invention relates generally to digestive disorders, and in particular to methods for treating irritable bowel syndrome by increasing carbohydrate absorption...
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