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Patent # Description
US-1,011,2985 Toll-like receptors
The present invention relates to toll-like receptors, to cells comprising such toll-like receptors, to methods for the detection of immunostimulatory...
US-1,011,2984 Light-sensitive chimeric GPCR protein
A light-sensitive chimeric protein includes domains from at least two members of the G-protein-coupled-receptor (GPCR) protein super family, which are fused to...
US-1,011,2983 Neuregulin variants and methods of screening and using thereof
The present invention provides polypeptide variants of neuregulin-1.beta. (NRG-1.beta.) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4....
US-1,011,2982 Detection of anti-neurochondrin autoantibody in patients with cerebellar ataxia or cerebellitis
Polypeptides including Neurochondrin and autoantibodies binding to polypeptides including Neurochondrin are provided. Methods for diagnosing or treating...
US-1,011,2981 Methods for treatment of stroke or cerebrovascular accidents using an ET.sub.B receptor agonist
Methods of using an ET.sub.B receptor agonist, such as IRL-1620, for the treatment of stroke or cerebrovascular accidents are disclosed. The ET.sub.B receptor...
US-1,011,2980 Mutated immunoglobulin-binding polypeptides
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A...
US-1,011,2979 Influenza vaccination
Influenza viruses have traditionally been administered by intramuscular injection. The invention is based on the idea of using alternative routes of delivery...
US-1,011,2978 Peptide and use thereof
An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The...
US-1,011,2977 Peptide for inducing multinucleation in cells, and use therefor
Provided are a synthetic peptide having a multinucleation-inducing activity that can cause multinucleation in a target cell, a multinucleation-inducing agent...
US-1,011,2976 Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for...
US-1,011,2975 Benzodiazepine dimers, conjugates thereof, and methods of making and using
Benzodiazepine dimers having a structure represented by ##STR00001## wherein R.sup.1 is ##STR00002## wherein the variables in formulae (I), (Ia), and (Ib)...
US-1,011,2974 Method for the production of 18F-labeled active esters and their application exemplified by the preparation of...
Novel efficient, time-saving and reliable radiofluorination procedures for the production of .sup.18F-labelled active esters via nucleophilic substitution of...
US-1,011,2973 Process for the preparation of ramipril
An enantioselective process for the production of (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid and its conversion into Ramipril is provided.
US-1,011,2972 Process for production of fibrinogen and fibrinogen produced thereby
A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing...
US-1,011,2971 Protein purification in the presence of nonionic organic polymers and electropositive surfaces
A method of purifying a desired protein from a preparation includes (a) providing the preparation in a form having less than about 5% of chromatin residing in...
US-1,011,2970 Process for the preparation of 17-desoxy-corticosteroids
The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the...
US-1,011,2969 Compositions and methods for sequencing nucleic acids
Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme...
US-1,011,2968 Inhibitors of protein methyltransferase DOT1L and methods of use thereof
The present invention relates to DOT1L inhibitors and methods of identifying, designing, or optimizing them. The present invention also relates to crystals of...
US-1,011,2967 Process for the preparation of sofosbuvir
A process for the synthesis of Sofosbuvir ##STR00001## is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) ...
US-1,011,2966 Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection...
US-1,011,2965 Bicyclic bridged metallocene compounds and polymers produced therefrom
Disclosed herein are catalyst compositions containing bicyclic bridged metallocene compounds. These catalyst compositions can be used for the polymerization of...
US-1,011,2964 Dithiolene metal complex colorless IR absorbers
The invention relates to the use of compounds of formulae (I) and/or (II) as colorless 1R absorbers wherein M is Ni, Pd, Pt, Au, Ir, Fe, Zn, W, Cu, Mo, In, Mn,...
US-1,011,2963 Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors
The present invention provides a compound of formula I; ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2 and R.sup.3 are...
US-1,011,2962 Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules...
Boron-based prodrugs of phenol- or aromatic hydroxyl group-containing therapeutic molecules ("original drugs"), uses thereof, and methods of making the same,...
US-1,011,2961 Hydroboration and borylation with cobalt catalysts
In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes are operable as catalysts for hydroboration and borylation...
US-1,011,2960 Methods for producing borylated arenes
Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes)...
US-1,011,2959 Metal complex and color conversion film comprising same
The present disclosure relates to a novel compound, a color conversion film, a backlight unit and a display device comprising the same.
US-1,011,2958 N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiaz- in-8a(8H)-YL)-1,3-thiazol-4-YL] amides
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have...
US-1,011,2957 Thiazolyl-containing compounds for treating proliferative diseases
The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein...
US-1,011,2956 Heterocyclic compounds having cholesterol 24-hydroxylase activity
An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or...
US-1,011,2955 Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer,...
US-1,011,2954 Bicyclic heteroaryl derivatives having inhibitory activity for protein kinase
The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof...
US-1,011,2953 11,13-modified saxitoxins for the treatment of pain
Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and...
US-1,011,2952 Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
Provided are certain fused tetra or penta-cyclic compounds and salts thereof, compositions thereof, and methods of use thereof.
US-1,011,2951 PDE1 inhibitor
The present invention provides a compound of Formula I: ##STR00001## useful for treating chronic kidney disease and diabetic kidney disease.
US-1,011,2950 Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
The present invention is directed to imidazo[1,2-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof, which are LSD1 inhibitors...
US-1,011,2949 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
US-1,011,2948 Benzamide or benzamine compounds useful as anticancer agents for the treatment of human cancers
The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds...
US-1,011,2947 Substituted 6-aminopurines for targeting HSP90
Described herein are 6-aminopurine compounds comprising formula (III) that may selectively bind to Hsp90, methods of using the compounds, and kits including the...
US-1,011,2946 Composition
Compound (I), and pharmaceutically acceptable salts thereof, are inducers of human interferon. Certain discrete and particular dosages of Compound (I) may be...
US-1,011,2945 Fused quinoline compunds as PI3K, mTOR inhibitors
The present invention relates to the compounds of formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient,...
US-1,011,2944 Heterocyclic compounds useful as inhibitors of TNF
Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CR.sub.6 or N; W is: (i) --(CR.sub.3R.sub.3).sub.1-4-- or (ii) ...
US-1,011,2943 Substituted imidazoles as gamma secretase modulators
The present invention is concerned with novel tricyclic 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione derivatives of Formula (I) ##STR00001## wherein...
US-1,011,2942 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Provided herein are compounds of the Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B,...
US-1,011,2941 Tricyclic compounds as anticancer agents
The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using...
US-1,011,2940 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
US-1,011,2939 Tied-back benzamide derivatives as potent rock inhibitors
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are...
US-1,011,2938 Indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives
The present invention is concerned with indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives of general formula I wherein Ar.sup.1, A.sup.2,...
US-1,011,2937 P2X7 modulators and methods of use
The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb). The invention also relates to pharmaceutical compositions comprising compounds...
US-1,011,2936 Five-membered heterocycles useful as serine protease inhibitors
The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically...
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