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Patent # Description
US-1,011,2935 Indazolyl thiadiazolamines and related compounds for inhibition of Rho-associated protein kinase and the...
The invention provides indazolyl thiadiazolamines and related compounds, pharmaceutical compositions, methods of inhibiting Rho-associated protein kinase, and...
US-1,011,2934 (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical...
US-1,011,2933 Methods and compositions for treatment of fibrosis
Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some...
US-1,011,2932 Benzoxazepin oxazolidinone compounds and methods of use
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: ...
US-1,011,2931 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
The invention is directed to a formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2a, R.sup.2b and...
US-1,011,2930 Compositions and methods for controlling nematodes
Compositions and methods for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds include oxazoles,...
US-1,011,2929 Lactams as inhibitors of rock
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
US-1,011,2928 Inhibitors of SYK
The present invention relates to the use of novel compounds of formula I: wherein all variable substituents are defined as described herein, which are SYK...
US-1,011,2927 Inhibitors of cyclin-dependent kinase 7 (CDK7)
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
US-1,011,2926 Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases...
US-1,011,2925 Methods for the preparation of charged crosslinkers
Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert...
US-1,011,2924 Piperdinyl nociceptin receptor compounds
The present invention provides novel piperidinyl-containing nociceptin receptor ligand compounds and pharmaceutical compositions useful in the treatment of...
US-1,011,2923 1,2,4-triazine-4-amine derivatives
According to the invention there is provided a compound of formula A1 which may be useful in the treatment of a condition or disorder ameliorated by the...
US-1,011,2922 Inhibitor of bruton's tyrosine kinase
Provided are a compound represented by formula (III) or pharmaceutically acceptable salts, solvates, active metabolites, polymorphs, esters, tautomers or...
US-1,011,2921 Method for preparation of thiophene-2-carbonyl chlorides with oxalyl chloride
The invention discloses a method for the preparation of thiophene-2-carbonyl chlorides starting from thiophenes with oxalyl chloride at elevated temperature...
US-1,011,2920 Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect...
US-1,011,2919 Methods of preparing oxa-bicycloalkene
Disclosed is a method of preparing an oxa-bicycloalkene via the reaction of a cycloalkanone and an allyl alcohol compound in the presence of an organic acid, a...
US-1,011,2918 15-oxospiramilactone derivatives, preparation method and uses thereof
The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically...
US-1,011,2917 Therapeutic compounds
The invention provides compounds formula (I) and salts thereof: wherein the bond represented by ---- is a single bond or a double bond, and R1 has any of the...
US-1,011,2916 HMF production from glucose in ionic liquid media
Methods of converting lignocellulosic derivatives form 5-hydroxymethyl furfural (HMF) in ionic liquids are provided herein. Glucose is enzymatically converted...
US-1,011,2915 3-aryl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with...
US-1,011,2914 Polymorphs of a mPGES-1 inhibiting triazolone compound
The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically ...
US-1,011,2913 Substituted [1,2,4]triazole and imidazole compounds as fungicides
The present invention relates to compounds of the formula I ##STR00001## wherein the variables are defined in the claims and the specification, to their...
US-1,011,2912 Homopiperazine-based catalysts for neutralization of organophosphorus-based compounds
Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques...
US-1,011,2911 Substituted cyanoguanidines as oral anti-virals
This disclosure relates to: (a) compounds and salts of formula (I), formula (II), formula (III), and formula (IV), that, inter alia, inhibit RSV infection...
US-1,011,2910 Catalysis of diketopiperazine synthesis
Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of .epsilon.-amino...
US-1,011,2909 Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of...
US-1,011,2908 Methods for producing optically active valeric acid derivatives
A method for producing a compound (4), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific...
US-1,011,2907 Substituted indazoles for treating tendon and/or ligament injuries
The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form ##STR00001## a method for manufacturing the...
US-1,011,2906 1-aryl-3-alkylpyrazole insecticides
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q is ##STR00002## and...
US-1,011,2905 Multifunctional aminoquinoline therapeutic agents
Aminoquinoline compounds useful for treating chronic pain, addiction, and other conditions are provided. The aminoquinoline compound is represented by Formula...
US-1,011,2904 Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline...
US-1,011,2903 Heterocyclic compounds for the treatment of neurological and psychological disorders
Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety...
US-1,011,2902 Fungicidal pyridylamidines
The invention relates to compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are as...
US-1,011,2901 Method for preparing dabigatran etexilate intermediate, and intermediate compound
Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate...
US-1,011,2900 Modified amino acids
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of...
US-1,011,2899 Isoindoline derivatives for use in the treatment of a viral infection
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds. ##STR00001##
US-1,011,2898 Process for the preparation of saroglitazar pharmaceutical salts
The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In...
US-1,011,2897 Substituted N-acetyl-L-cysteine derivatives and related compounds
Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or...
US-1,011,2895 Antivirals against molluscum contagiosum virus
This invention provides compounds of formulas (I)-(XIV) as defined in the specification, and pharmaceutical compositions comprising the same, and methods of...
US-1,011,2894 Cyclic process for producing taurine
There is disclosed a process for producing taurine from aziridine by (a) adding gaseous aziridine or a solution of aziridine to a solution of ammonium...
US-1,011,2893 Guanidinium compounds
The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties...
US-1,011,2892 Process for preparing polyisocyanates
The present invention relates to a continuous process for preparing a polyisocyanate, in which a polyamine and phosgene are first converted predominantly to...
US-1,011,2891 Stereoselective process to obtain (Z)-5-cyclyloxy-2-[(E)-methoxyimino]-3-methyl-pent-3-enic acid methyl ...
The present invention relates to a process for preparation of intermediates (Z,2E)-5-hydroxy-2-methoxyimino-N-methyl-pent-3-enamides from 4-substituted...
US-1,011,2890 Compound, salt of compound, external agent for skin, cosmetic, and food additive
Provided is a compound represented by Formula (1) or a salt thereof (in the formula, R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a...
US-1,011,2889 Continuous process for producing a surfactant in a tube reactor
The invention relates to a continuous method for producing a tenside, containing a compound of the formula (1), wherein R.sup.2 is a fatty acid alkyl residue...
US-1,011,2888 Nitroxide hydroxylamine and phenylenediamine combinations as polymerization inhibitors for ethylenically...
Polymerization inhibitor compositions are provided. The polymerization inhibitor compositions may include at least one hydroxylamine of a nitroxide and at least...
US-1,011,2887 Catalysts based on amino-sulfide ligands for hydrogenation and dehydrogenation processes
The present application discloses novel amino-sulfide metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated...
US-1,011,2886 Method for purification of benzoic acid
The present invention relates to a method for purifying a crude benzoic acid (32) containing 5 to 20% by weight of byproducts and 80 to 95% by weight of benzoic...
US-1,011,2885 Process and system for producing acrylic acid
A process for recovering (meth)acrylic acid includes distilling a mixture comprising (meth)acrylic acid in a finishing column at less than atmospheric pressure...
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