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Patent # Description
US-1,023,2050 Multi-functional particles and methods of using the same
Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one...
US-1,023,2049 Targeted therapeutics
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a...
US-1,023,2048 Apitherapy method and composition
A bee venom composition and method for preparing such a composition. The bee venom can be placed in a base that allows it to be applied directly to the skin....
US-1,023,2047 Topical oil composition for the treatment of fungal infections
The present invention is directed to anti-fungal compositions comprising an anti-fungal agent, an oil and excipients or additives. The compositions of the...
US-1,023,2046 Hemostatic microspheres
Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked...
US-1,023,2045 Easy to swallow coatings and substrates coated therewith
The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates...
US-1,023,2044 Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and...
US-1,023,2043 Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and...
Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to...
US-1,023,2042 Conjugates of an anti-TNF-alpha antibody
Conjugates of an anti-TNF antibody and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is...
US-1,023,2041 Combination of lenalidomide and polypeptide construct, and uses thereof
Methods for cancer treatment include administering to a cancer patient an anti-CD38 antibody-attenuated human IFN alpha-2b construct and lenalidomide or...
US-1,023,2040 Anti-B7 H1 and anti-CTLA-4 antibodies for treating non-small cell lung cancer
Provided herein are methods of treating non-small cell lung cancers comprising administering an effective amount of MEDI4736 or an antigen-binding fragment...
US-1,023,2039 Compositions and methods for the treatment of tissue fibrosis
Provided are methods of treating tissue fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a...
US-1,023,2038 Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response
The present invention relates to the use of a recombinant LAG-3 or derivatives thereof in order to boost a monocyte-mediated immune response, in particular to...
US-1,023,2037 Supramolecular hydrogel of fMLF-based molecules and use thereof
The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing...
US-1,023,2036 Vaccine formulation, preparation method therefor and use thereof
The present invention provides a vaccine formulation, a preparation method therefor and a use thereof. The vaccine formulation comprises a vaccine carrier and...
US-1,023,2035 Conditionally replication deficient herpes virus and use thereof in vaccines
The present invention is directed to a mutated recombinant herpesvirus, e.g., varicella zoster virus (VZV) and simian varicella virus strains or HSV-1 or HSV-2...
US-1,023,2034 Compositions comprising CH505 envelopes, and trimers
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce...
US-1,023,2033 Respiratory syncytial virus vaccine
A respiratory syncytial virus (RSV) vaccine comprising a recombinant fusion protein antigen. In one embodiment, the recombinant fusion protein antigen comprises...
US-1,023,2032 Recombinant RSV with silent mutations, vaccines, and methods related thereto
In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (RSV). In certain embodiments, the disclosure...
US-1,023,2031 Influenza virus reassortment
New influenza donor strains for the production of reassortant influenza B viruses are provided.
US-1,023,2030 Vaccines for human papilloma virus and methods for using the same
Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV6 E6E7, HPV11...
US-1,023,2029 Compositions comprising N. meningitidis proteins
The invention relates to immunogenic compositions comprising at least two Neisseria meningitidis (Nm) protein antigens selected from the group consisting of a...
US-1,023,2028 Compounds and methods for affecting cytokines
The present invention discloses isolates and fractions from a phyto-percolate and methods for affecting various cytokines by administering an effective amount...
US-1,023,2027 Live attenuated Edwardsiella ictaluri vaccine and method of using the same
A live attenuated Edwardsiella ictaluri bacterium lacking a viable gene encoding a functional evpB protein and a method of using the same to protect fish...
US-1,023,2026 Vaccine for mycoplasma infection
Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic...
US-1,023,2025 Method for minimising progression of cancer in companion animals
The invention relates to minimizing the progression of cancer in a companion animal using P2X.sub.7 immunotherapy.
US-1,023,2024 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal...
The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising an...
US-1,023,2023 Methods for treatment of and prophylaxis against inflammatory disorders
An isolated and purified peptide, neonatal NET-inhibitory Factor (nNIF), is disclosed. Methods for treatment of and prophylaxis against inflammatory disorders...
US-1,023,2022 Lyophilized recombinant VWF formulations
Long-term stable pharmaceutical formulations of lyophilized recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations...
US-1,023,2021 Calcitonin mimetics for treating diseases and disorders
Calcitonin mimetic peptides having an amino acid sequence in accordance with SEQ ID NO:8 or SEQ ID NO:53, each of which may be carboxylated at its N-terminal or...
US-1,023,2020 Incretin-insulin conjugates
Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and...
US-1,023,2019 Method of treating hyperglycemic disorders using apolipoprotein AIV
Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are...
US-1,023,2018 ACTH for treatment of acute respiratory distress syndrome
Provided herein are methods of treatment of acute respiratory distress syndrome comprising administration of adrenocorticotropic hormone (ACTH). or fragment,...
US-1,023,2017 Method of treating cancer by administering tumor necrosis factor receptor ligand superfamily (TNFRSF)...
Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The...
US-1,023,2016 Methods for treating congestive heart failure
The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like...
US-1,023,2015 Sugar compositions for treating hemophilia A and/or Von Willebrand disease
The invention relates to compositions comprising an isolated sugar for use in the treatment of von Willebrand disease and/or hemophilia A, wherein the sugar is...
US-1,023,2014 Tear lipocalin muteins binding IL-4 R alpha
The present invention relates to novel muteins derived from human tear lipocalin, which bind to IL 4 receptor alpha. The sequences of the muteins comprise...
US-1,023,2013 Use of an antimicrobial peptide TP4 in treating a cancer
The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or...
US-1,023,2012 Intracellular pH-responsive fusion peptide and pharmaceutical composition for reducing abnormal prion protein...
A pH-responsive fusion peptide according to the present disclosure, containing a cell-penetrating peptide exhibiting a positive charge, which contains 2-15...
US-1,023,2011 Formulations of guanylate cyclase C agonists and methods of use
The invention provides low-dose formulations of guanylate cyclase-C ("GCC") agonist peptides and methods for their use. The formulations of the invention can be...
US-1,023,2010 Compositions and methods for treatment of radiation exposure
The present invention relates to an immunostimulant and to the use of an immunostimulant in the form of a cross-linked muramyl dipeptide microparticle in the...
US-1,023,2009 Peptide for promoting wound healing, its composition and method of using the same
Disclosed is a peptide consisting of an amino acid sequence of HisThrSerThrGluAlaLys (SEQ ID NO: 1). This peptide is effective in the enhancement of fibroblast...
US-1,023,2008 Multi-purpose nutritional supplement composition
One or more multi-purpose compositions formulated for pre-operative, post-operative, pregnancy, and postpartum recovery are disclosed in liquid or solid form,...
US-1,023,2007 High molecular weight polysaccharide that binds and inhibits virus
This invention provides a high molecular weight polysaccharide capable of binding to and inhibiting virus and related pharmaceutical formulations and methods of...
US-1,023,2006 Pharmaceutical composition comprising refined indigo naturalis extract and the use thereof
A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active...
US-1,023,2005 Compositions and methods for controlling carbohydrate and fat metabolism
A composition comprising at least a mixture of molecules obtained at least from: Chrysanthellum indicum, Cynara scolymus, and Vaccinium myrtillus and wherein...
US-1,023,2004 Pharmaceutical composition based on Centella asiatica (Hydrocotyle asiatica L.) for the treatment of lower limb...
A pharmaceutical composition based on centella asiatica (Hydrocotyle asiatica L.) for the treatment of lower limb ulcers, including as active ingredients,...
US-1,023,2003 Exogenous tap inhibitor armed oncolytic viruses and therapeutic uses thereof
The present invention relates to exogenous TAP inhibitor armed oncolytic viruses that replicate selectively in cancer cells, evade CD8+ cytolytic T-cells, and...
US-1,023,2002 Oncolytic HSV1 vectors and methods of using the same
Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides an...
US-1,023,2001 Selection and use of lactic acid bacteria preventing bone loss in mammals
The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been...
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