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Patent # Description
US-1,023,9914 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
An improvement of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high...
US-1,023,9913 Compounds and methods involving sterols
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The...
US-1,023,9912 Modulators of 5'-nucleotidase, ecto and the use thereof
Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the...
US-1,023,9911 Beta-D-2'-deoxy-2'-alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substi- tuted purine nucleotides for HCV...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to...
US-1,023,9910 Process for the preparation of sofosbuvir
The present invention relates to an improved, commercially viable and industrially advantageous process for the preparation of sofosbuvir, which uses reagents...
US-1,023,9909 Polymethine compounds with long stokes shifts and their use as fluorescent labels
The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic...
US-1,023,9908 Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further...
US-1,023,9906 Apparatus and method for obtaining glycoglycerolipids and glycosphingolipids from lipid phases
The present invention relates to an apparatus and method for separating glycoglycerolipids and also glycoglycerolipids and glycosphingolipids from a lipid phase...
US-1,023,9905 Low temperature and efficient fractionation of lignocellulosic biomass using recyclable organic solid acids
Methods of fractionating lignocellulosic biomass using hydrotropic sulfonic acids are provided. Also provided are methods of forming lignin particles, furans,...
US-1,023,9904 Method for producing solid lignin
Lignin-rich starting material is suspended in a first medium, which is acidic and aqueous, to form a aqueous acidic suspension, which is heated and allowed to...
US-1,023,9903 Pt (IV) derivatives and nanocarriers comprising them
Provided are Pt (IV) lipophilic derivatives for improved drug performance in cancer therapy, as well as nanocarriers including the same.
US-1,023,9902 Stable peptide-conjugated ascorbic acid derivative, method for preparing same, and cosmetic composition...
The present invention provides a stable peptide-conjugated, ascorbic acid derivative, a method for preparing the same, and a cosmetic composition comprising the...
US-1,023,9900 Processes for producing organophosphorous compounds
The present invention relates to processes for producing organophosporous compositions having low acid content as well as processes for reprocessing partially...
US-1,023,9898 Compounds based on adducts with isocyanates for coating compositions
The present invention relates to compounds based on adducts with isocyanates. The present invention further relates to a method for preparation thereof,...
US-1,023,9897 Bortezomib-based delivery system
The invention relates to a class of molecules obtained for conjugating a species or substrate to Bortezomib by means of bonds of the boronic diester type which...
US-1,023,9896 Hydrosilylation iron catalyst
A hydrosilylation iron catalyst prepared from a two-electron ligand (L) and a mononuclear, binuclear, or trinuclear complex of iron indicated by formula (1), Fe...
US-1,023,9895 Compound for specifically binding to amyloid .beta.-protein
Provided is a compound for specifically binding to amyloid .beta.-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section...
US-1,023,9894 Inhibitors of indoleamine 2,3-dioxygenase
Provided are compounds of formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and...
US-1,023,9893 Controlling the isomerization rate of Azo-BF2 switches using aggregation
Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans...
US-1,023,9892 Method for producing alkyl-indium compounds and the use thereof
The invention relates to a method for the cost-effective and environmentally friendly production of alkyl indium sesquichloride in high yield and with high...
US-1,023,9891 Compositions to detect remnant cancer cells
Disclosed are compounds, compositions and methods for detecting remnant cancer cells in a tissue sample.
US-1,023,9890 Broad spectrum beta-lactamase inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
US-1,023,9889 Pentacyclic compound
The present invention provides compounds represented by formulas (1) to (VI) or pharmaceutically acceptable salts thereof: ##STR00001##
US-1,023,9888 Targeted protein degradation using a mutant E3 ubiquitin ligase
The present application provides bifunctional compounds of Formula I or II: ##STR00001## or an enantiomer, diastereomer, or stereoisomer, or a ...
US-1,023,9887 Positive allosteric modulators of the muscarinic acetylcholine receptor M4
Disclosed herein are tricyclic compounds, including pyrimido[4',5':4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-4-amine, ...
US-1,023,9886 Polymer compound and organic semiconductor device using the same
A polymer compound comprising a structural unit represented by the formula (1): ##STR00001## wherein a ring A and a ring B represent a heterocyclic ring. A...
US-1,023,9885 Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-.alpha.]pyrazin-3-yl)phe- nyl]ethyl]-3-(p-tolylsulfonyl)urea...
The present invention describes novel compounds, or veterinary or pharmaceutically acceptable salts thereof, veterinary or pharmaceutical compositions thereof,...
US-1,023,9884 Coelenterazine compounds and uses thereof
There is provided a series of coelenterazine (CTZ) derivatives as a substrate with high luminescence intensity, which is optimal for maximum luminescence...
US-1,023,9883 4-imidazopyridazin-1-yl-benzamides as BTK inhibitors
The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) ##STR00001## or a pharmaceutically acceptable salt...
US-1,023,9881 RIPK2 inhibitors and method of treating cancer with same
The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided...
US-1,023,9880 Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting...
The present invention provides a compound of Formula I, and salts thereof, and a pharmaceutical composition comprising a compound of Formula I: ##STR00001## ...
US-1,023,9879 Process for producing purinone derivative
According to the present invention, differently from well-known production methods, with the use of a different starting material, Ullmann condensation which...
US-1,023,9878 Macrocyclic ligands with pendant chelating moieties and complexes thereof
The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
US-1,023,9877 Pharmacophore for trail induction
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for...
US-1,023,9876 Triaza-spirodecanones as DDR1 inhibitors
The present invention relates to compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein L and R.sup.1 to R.sup.5 are as...
US-1,023,9875 Naphthyridinyl hydrazine derivatives as potent peripheral analgesic agents
The naphthyridinyl hydrazine derivatives as potent peripheral analgesic agents are (E)-2-(substituted benzylidene)-1-(2,7-dialkyl-1,8-naphthyridinyl) hydrazines...
US-1,023,9873 7-azaindole or 4,7-diazaindole derivatives as IKK epsilon and TBK1 inhibitor and pharmaceutical composition...
Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKK.epsilon. (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The...
US-1,023,9872 Therapeutic agents for the treatment of HBV infection
The disclosure includes compounds of Formula (I) ##STR00001## wherein Z.sub.1, Z.sub.2, Z.sub.3, X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6,...
US-1,023,9871 Compounds and methods for regulating integrins
A method of treating inflammation, by administering an effective amount of a .beta.2 integrin agonist to a patient, and reducing inflammation. A method of...
US-1,023,9870 Dopamine D3 receptor antagonists
The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical...
US-1,023,9869 Sulfonamide compounds as voltage-gated sodium channel modulators
The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the...
US-1,023,9868 5-hydroxytryptamine receptor 7 activity modulators and their method of use
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases...
US-1,023,9867 Modulators of ATP-binding cassette transporters
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters...
US-1,023,9866 Selective methods for the separation of ondansetron and related impurities
The present disclosure generally relates to methods for separating ondansetron and related impurities using CO.sub.2-based chromatography.
US-1,023,9865 Bisphenols containing pendant clickable maleimide group and polymers therefrom
The patent discloses bisphenol monomers of formula I with pendant maleimide group connected via alkylene spacer and preparation thereof. Also, it discloses...
US-1,023,9864 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof
Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cell-proliferation inhibitors, and therapeutic uses and methods of preparation thereof,...
US-1,023,9863 Factor XIa inhibitors
The present invention provides a compound of Formula (I) ##STR00001## and pharmaceutical compositions comprising one or more said compounds, and methods for...
US-1,023,9862 Benzazepine compounds, conjugates, and uses thereof
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed...
US-1,023,9861 Therapeutic compounds and uses thereof
The invention relates to compounds of formula (I) and salts thereof: ##STR00001## wherein R.sup.1-R.sup.3 have any of the values defined in the specification....
US-1,023,9859 Nitrogen-containing heterocycles as pesticides
The present application relates to novel heterocyclic compounds, to processes and intermediates for the preparation thereof, and their use for controlling...
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