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Patent # Description
US-1,023,9858 Process for making compounds for use in the treatment of cancer
Disclosed herein is a process of making a compound of formula I ##STR00001## The compound of formula I is an inhibitor of MEK and thus can be used to treat...
US-1,023,9857 Processes for the preparation of 2-thiophenecarbonyl chloride
Provided herein are processes for the preparation of 2-thiophenecarbonyl chloride, which is useful, for example, in the preparation of ...
US-1,023,9856 Synthesis of resorcylic acid lactones useful as therapeutic agents
Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical...
US-1,023,9855 Process for preparing oroxylin A
A process for preparing oroxylin A includes: subjecting baicalin to a methylation reaction using a methylating reagent in the presence of a base to methylate...
US-1,023,9854 Compounds, compositions and methods for treating or preventing a symptom associated with gout or hyperuricemia
The inventive subject matter provides compounds, compositions and methods for lowering serum acid (sUA) for the treatment of gout, and having reduced liver...
US-1,023,9853 Polycyclic phosphoramidtes and their applications
The present invention is generally directed to fluorescent dyes useful for preparing fluorescent oligonucleotides, and the use of the fluorescent...
US-1,023,9852 Process for the production of 5-hydroxymethylfurfural in the presence of organic catalysts from the thiourea family
A process for the transformation of a feed of at least one sugar into 5-hydroxymethylfurfural, contacting the feed with one or more organic catalysts in the...
US-1,023,9851 Carboxylic acid derivatives and use thereof in the preparation of prodrugs
The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the...
US-1,023,9850 14-hydroxy-docosahexaenoic acid compounds
The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
US-1,023,9849 Cyanopyridine derivatives as liver X receptor beta agonists, compositions, and their use
In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein...
US-1,023,9848 Cyclohexenyl compounds, compositions comprising them and uses thereof
Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated...
US-1,023,9847 Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione
Provided herein is a composition, method of manufacture, and method for treating a disease condition and/or raising cellular levels of glutathione, the...
US-1,023,9846 Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods...
US-1,023,9845 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
US-1,023,9844 Disubstituted triazole analogs
The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are...
US-1,023,9843 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R.sub.1a,...
US-1,023,9842 Hydrosoluble compounds derived from benzimidazole used in treating fasciolosis
The present invention relates to hydrosoluble compounds derived from benzimidazole represented by general formula I: ##STR00001## wherein: Y.sup.1 e Y.sup.2...
US-1,023,9841 Method for producing pyrazole derivative
The invention relates to a production method of pyrazole derivative (6) by reacting compound (5) with an oxidant. ##STR00001## wherein R.sup.1, R.sup.2,...
US-1,023,9840 Benzoazepine derivatives
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds. ##STR00001##
US-1,023,9839 Compounds and formulations suitable for radical scavenging
The present invention relates to compositions and methods of using free radical scavengers with reduced .sup.1O.sub.2 generation. In certain embodiments, these...
US-1,023,9838 Heteroaryl orexin receptor antagonists
The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
US-1,023,9837 Piperidine derivatives as HDAC1/2 inhibitors
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders...
US-1,023,9836 Benzenecarbothioccyclopenta[c] pyrrole-1,3-dione compounds and process for synthesis thereof
The present invention relates to a novel analogs of benzenecarbothioccyclopenta[c]pyrrole-1,3-dione of formula (I) useful for treating various viral infections...
US-1,023,9835 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B
The present invention relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment...
US-1,023,9834 Antibiotic sensitivity-restoring and photosensitive agents
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to...
US-1,023,9833 Intermediates, their process and use in preparation of selective .alpha.1-adrenoceptor antagonists, Silodosin
The present invention provides novel process for the preparation of the .alpha.1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts...
US-1,023,9832 N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase...
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and...
US-1,023,9831 Method for producing bis(3-aminophenyl)disulfides and 3-aminothiols
The present invention relates to a novel method for preparing bis(3-aminophenyl) disulphides of the general formula (I) and 3-aminothiols of the general formula...
US-1,023,9830 Benzenesulfonamide upregulators of NPC1 for Neimann-Pick disease and other lysosomal storage disorders
Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly...
US-1,023,9828 Process for preparing guanidino-functional monomers
A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one...
US-1,023,9827 Bis[3-isopropenyl-.alpha.,.alpha.-dimethylbenzyl]carbodiimide, production methods, and use of said compound
The present invention relates to novel processes for producing bis[3-isopropenyl-.alpha.,.alpha.-dimethylbenzyl]carbodiimide, to the thus-produced ...
US-1,023,9826 Method for producing isocyanates
A method for producing isocyanates by reacting primary amines with phosgene in a stoichiometric excess in the gas phase, wherein the excess phosgene is...
US-1,023,9825 Ketamine derivatives
The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising...
US-1,023,9824 Automated synthesis of small molecules using chiral, non-racemic boronates
Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to...
US-1,023,9823 Process for purifying long chain amino acids
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the...
US-1,023,9822 Process for the separation of long chain amino acids and dibasic acids
There is disclosed a process for the separation of long chain dibasic acid and fatty acid, comprising: (1) reacting a mixture of long chain dibasic acid and...
US-1,023,9821 Process for the co-production of long chain amino acids and dibasic acids
There is disclosed a process for the co-production of long chain .omega.-amino acid and long chain dibasic acid, comprising: (1) reacting long chain ketoacid...
US-1,023,9820 Etheramine compounds
Embodiments described herein provide a compound that may be used in a variety of applications such as corrosion inhibition, additives for metalworking, mining...
US-1,023,9819 Methods for producing an ester of an alpha, beta-unsaturated carboxylic acid
A method for producing esters of an alpha, beta-unsaturated carboxylic acid are disclosed, the method includes reacting a three or four carbon ...
US-1,023,9818 Method for producing diesters of terephthalic acid with circulation of the reaction mixture
The present invention relates to a process for preparing a terephthalic diester by reacting terephthalic acid with at least one alcohol, wherein terephthalic...
US-1,023,9817 Process for the preparation of (1R,3R)- and (1S,3S)-2,2-dihalo-3-(substituted phenyl)cyclopropanecarboxylic acids
The (1R,3R)- or (1S,3S)-enantiomer of 2,2-dichloro-3-(substituted phenyl)cyclopropane-carboxylic acid is prepared in a process involving chemical resolution of...
US-1,023,9816 Process for producing (meth)acrylic acid
The invention is directed to a process for recovering/purifying (meth)acrylic acid which does not use azeotropic solvent and is based on the use of two columns...
US-1,023,9815 Method for producing acrylic acid
The objective of the present invention is to provide a method for efficiently producing acrylic acid while troubles not only in a waste oil handling after...
US-1,023,9814 Process for the purification of levulinic acid
A process for the purification of levulinic acid including the following steps: a. providing a composition 1, comprising at least 75 wt. % of levulinic acid; b....
US-1,023,9813 Method for producing calcium dipropionate
The invention relates to a method for the production of calcium dipropionate by a batch process in a single pressure-resistant reaction vessel. The reaction...
US-1,023,9812 Systems and methods for synthesis of phenolics and ketones
Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing...
US-1,023,9810 Process for aldehyde manufacture
The process of the invention is a process for the production of an aldehyde from the corresponding alcohol comprising the steps of feeding to a reactor a feed...
US-1,023,9809 Methods for preparing bridged bi-aromatic ligands
New methods of preparing bridged bi-aromatic ligands are disclosed. The methods employ direct di-ortho-lithiation of aromatic rings of bridged protected...
US-1,023,9808 Cannabis extracts
A method is provided for removing THC from raw cannabis oil.
US-1,023,9807 Fused cyclooctyne compounds and their use in metal-free click reactions
The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused...
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