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Patent # Description
US-1,024,6514 Single domain antibodies that bind to human CD20
Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful...
US-1,024,6513 Antibodies, compounds and derivatives thereof for use in the treatment of male infertility
The present invention relates to antagonists or inhibitors, which bind selectively to RANKL/OPGbp and regulate the interaction between RANKL/OPGbp and RANK/OPG....
US-1,024,6512 IL-2R beta/common gamma chain antibodies
Anti-CD122 and/or .gamma.c antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses...
US-1,024,6511 Fusion polypeptide capable of binding simultaneously to VEGF-C and VEGF-D
A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and...
US-1,024,6510 KIR3DL2 binding agents
The present invention relates to methods for the treatment of cancer and inflammatory disease using antibodies (e.g. monoclonal antibodies), antibody fragments,...
US-1,024,6509 Restricted immunoglobulin heavy chain mice
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human V.sub.H gene segment, a...
US-1,024,6508 Anti eotaxin-2 antibodies that recognize additional CCR3-binding chemokines
Provided are isolated polyspecific antibodies directed to a unique epitope in the chemokine eotaxin 2. The antibodies bind additional CCR3-binding chemokines....
US-1,024,6507 Polypeptide, anti-VEGF antibody, and anti-c-Met/anti-VEGF bispecific antibodies comprising the same
A polypeptide, an anti-VEGF antibody and an anti-c-Met/anti-VEGF bispecific antibody, which includes the polypeptide, a pharmaceutical composition including the...
US-1,024,6506 Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by...
Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic...
US-1,024,6505 Chimeric antigen receptors to control HIV infection
The present disclosure is directed to novel multispecific chimeric antigen receptor (CAR) proteins and DNA sequences encoding these proteins. The CARs comprise...
US-1,024,6504 Engineered receptor and their use
Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein....
US-1,024,6503 Method of improving the pharmacokinetic profile of a therapeutic polypeptide and the use thereof
The present invention provides a fusion protein comprising a therapeutic polypeptide fused to one or more flexible unstructured polypeptides and a trimeric...
US-1,024,6502 IL22 immunoconjugates
The application relates to a conjugate comprising interleukin-22 (IL22) and an antibody molecule. The antibody molecule preferably binds an antigen associated...
US-1,024,6501 Fusion polypeptides and methods of use
Disclosed are fusion polypeptides comprising fragments from a first and a second isoform of an interferon lambda family, nucleic acids encoding the fusion...
US-1,024,6500 Human cytolytic fusion proteins
The technology provided herein relates to novel human cytolytic fusion proteins (hCFPs) suitable to induce apoptosis in human cells comprising a target...
US-1,024,6499 Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis
A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds...
US-1,024,6498 Genetically encoded histone reporter allele constructs
Non-FRET-based fusion protein reporter molecules are provided that can be used to monitor histone modifications in living cells. Transgenic animals,...
US-1,024,6496 Potassium channel blockers and use thereof in the treatment of autoimmune diseases
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are...
US-1,024,6495 Variants of Gal2 transporter and their uses
The present invention relates to polypeptides which are Gal2 variants comprising at least one amino acid substitution at a position corresponding to T354, and...
US-1,024,6494 Polypeptides and antibodies for treating HBV infection and related diseases
The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope...
US-1,024,6493 De novo structural protein design for manufacturing high strength materials
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming...
US-1,024,6492 Botulinum assay with synaptobrevin substrate moiety
Compositions and methods for analyzing intracellular BoNT protease activity, and especially BoNT/B, BoNT/G, BoNT/D, and/or BoNT/F protease activity are...
US-1,024,6491 Peptidomimetic macrocycles and use thereof in regulating HIF1alpha
The present invention provides peptidomimetic macrocycles capable of regulating HIF1.alpha. and methods of using such macrocycles for the treatment of diseases.
US-1,024,6490 Conotoxin peptide .kappa.-CPTX-BTL02, preparation method therefor, and uses thereof
Provided is a new conotoxin peptide .kappa.-CPTx-btl02. The conotoxin peptide .kappa.-CPTx-btl02 has derivative polypeptide that has an amino acid sequence...
US-1,024,6489 Peptide inhibitors of calcium oxalate monohydrate crystallization and uses thereof
In an embodiment, the present disclosure pertains to a composition for inhibiting calcium oxalate monohydrate crystal growth comprising at least one isolated...
US-1,024,6488 Use of inhibitory peptides for the treatment of inflammatory diseases
An isolated peptide is disclosed which comprises an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1 (PERYQNLSPV),...
US-1,024,6487 Azaindoline compounds as granzyme B inhibitors
Azaindoline compounds as granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous...
US-1,024,6486 Macrocyclic inhibitors of flaviviridae viruses
Provided are compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods...
US-1,024,6485 Method to concentrate von willebrand factor or complexes thereof
The present invention relates to a method for concentrating von Willebrand Factor (VWF) from an aqueous solution comprising precipitating the VWF by providing...
US-1,024,6484 Method for purifying recombinant protein
A method is provided for purifying a recombinant protein from a mixture comprising the recombinant protein and related proteins, comprising the steps of: A....
US-1,024,6483 Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
The present invention provides compounds of Formula I: ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
US-1,024,6482 Neuroactive steroids, compositions, and uses thereof
Described herein are steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4, R.sup.5a,...
US-1,024,6481 Bile acid derivatives and methods for synthesis and use
Provided herein, inter alia, are methods for the preparation of modulators of farnesoid X receptor (FXR), and compositions and uses of the modulators of FXR.
US-1,024,6480 Compounds for the treatment of cancer
Provided herein are compounds useful for the treatment of cancer.
US-1,024,6479 Method of preparation of nanopore and uses thereof
This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide...
US-1,024,6478 Polyene macrolide derivative
The present invention is the following Amphotericin B derivative: ##STR00001## wherein each symbol is defined in description. The compound of the present...
US-1,024,6477 Isomerisation of C4-C6 aldoses with zeolites
The present invention relates to isomerization of C4-C6 aldoses to their corresponding C4-C6 ketoses. In particular, the invention concerns isomerization of...
US-1,024,6476 Method for preparing D-psicose crystal
A method for producing high purity D-psicose crystals having a purity of 98% (w/w) or more and a grain size of MA200 or more. The method includes: removing...
US-1,024,6475 Multidentate dinuclear cyclometallated platinum complexes containing N-(pyrimidin-2-yl)-carbazole and its analogues
Disclosed herein are multidentate dinuclear cyclometallated platinum complexes. The complexes are suitable as emitting materials or host materials in OLED...
US-1,024,6474 Preparation of a hydroxyalkyl phosphonic acid
The present invention is a process for converting a phosphonate to a hydroxyalkyl phosphonic acid comprising the step of contacting together water, the...
US-1,024,6473 Process for preparing an acryloyloxysilane
A process for purifying an acryloyloxysilane comprising subjecting a mixture comprising an acryloyloxysilane, a haloorganoalkoxysilane, and an alkane-based...
US-1,024,6472 Guanidine-functionalized particles and methods of making and using
Guanidine-functionalized particles and methods of making and using such particles.
US-1,024,6471 ETP derivatives
Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.
US-1,024,6470 Heterocyclic compounds
The present invention relates to a compound (3S)-3-(4-((3-(6-Oxa-3-azabicyclo[3.1.1]heptan-3-ylmethyl)benzyl)oxy)phen- yl)hex-4-ynoic acid methods for use of...
US-1,024,6469 Biaryl kinase inhibitors
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such...
US-1,024,6468 BACE1 inhibitors
The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture pharmaceutical compositions containing them and...
US-1,024,6467 Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
The present invention encompasses compounds of formula (I) wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as...
US-1,024,6466 Diaryl macrocycles as modulators of protein kinases
The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods...
US-1,024,6465 Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opioid receptor and more...
US-1,024,6464 Thienopyrimidine and thienopyridine compounds and methods of use thereof
The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but...
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