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Patent # Description
US-1,024,6463 Hypoxia-inducible factor 1 (HIF-1) inhibitors
Embodiments of small molecule inhibitors of hypoxia inducible factor 1 (HIF-1) and pharmaceutical compositions thereof are disclosed. The disclosed compounds...
US-1,024,6462 Chemokine receptor modulators and uses thereof
Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.
US-1,024,6461 Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
The invention relates generally to pharmaceutical tablet compositions comprising fumaric acid and the compound ...
US-1,024,6460 Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H- ...
The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benz- o[e]azulenes. Also...
US-1,024,6459 Use of tetramic acid derivatives as nematicides
Use of a tetramic acid compound according to formula (I) or (I') with a second nematicide as a treatment for crop plants to combat and control nematodes in the...
US-1,024,6458 Ergoline compounds and uses thereof
Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or...
US-1,024,6457 Indazole and azaindazole Btk inhibitors
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof,...
US-1,024,6456 IRAK4 inhibiting agents
Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
US-1,024,6455 Histone deacetylase inhibitors
Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of...
US-1,024,6454 Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3,...
US-1,024,6453 Benzenesulfonamide compounds and their use as therapeutic agents
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable...
US-1,024,6452 Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto
This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce...
US-1,024,6451 Propionic acid derivatives and methods of use thereof
Provided herein are compounds and pharmaceutical compositions of formula I ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and R.sup.6 are...
US-1,024,6450 Modulators of calcium release-activated calcium channel
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and...
US-1,024,6449 1,2,3 triazole-thiazole compounds, process for preparation and use thereof
A 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically acceptable salt thereof, process for its preparation, its pharmaceutical composition and...
US-1,024,6448 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists
The invention relates to compounds acting as antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I): ...
US-1,024,6447 3-(6-chloro-3-oxo-3,4-dihydro-(2H)-1,4-benzoxazin-4-yl) propanoic acid derivatives and their use as KMO inhibitors
Compounds of formula (I) ##STR00001## wherein: R.sup.1 is heteroaryl optionally substituted by methyl, ethyl, halo or .dbd.O; and R.sup.2 is H, methyl or...
US-1,024,6446 Blockers of the growth hormone receptor in disease prevention and treatment
Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1,...
US-1,024,6445 Method for producing benzoxazole compound
A method is provided for producing a compound represented by formula (3), wherein n is 1, 2, 3 or 4, by mixing a compound represented by formula (2), a...
US-1,024,6444 1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions
Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases...
US-1,024,6443 Cyanoquinoline derivatives
Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically...
US-1,024,6442 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors
Aminoquinazolinyl compounds of formula (I) are described, ##STR00001## which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in...
US-1,024,6441 Aromatic amine derivative, and organic electroluminescent element
An aromatic amine derivative including a substituent A and a substituent B each represented by the formula (1) or (2) and having an arylene group bound to a...
US-1,024,6440 Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR .gamma. (T))
Indazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of...
US-1,024,6439 Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: ##STR00001## which inhibit the Apoptosis...
US-1,024,6438 Non-selective kinase inhibitors
Disclosed herein are compounds, compositions, and methods for preventing and treating proliferative diseases associated with aberrant receptor tyrosine kinase...
US-1,024,6437 Crystal form of neratinib maleate and preparation method therefor
The present invention relates to novel crystalline forms of Neratinib maleate and the preparation method thereof. The novel crystalline forms of Neratinib...
US-1,024,6436 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making...
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating...
US-1,024,6433 Aryl and heteroaryl fused lactams
This invention relates to compounds of general formula (I) ##STR00001## in which R.sup.1, R.sup.2, U, V, L, M, R.sup.5, m, X, Y and Z are as defined herein,...
US-1,024,6432 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
The disclosures herein relate to novel compounds of formula wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and n are defined herein, and their use in treating,...
US-1,024,6431 Process to extract and purify .DELTA..sup.9-tetrahydrocannabinol
.DELTA..sup.9-THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent....
US-1,024,6430 Methods for producing Beraprost and its derivatives
The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
US-1,024,6429 Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula...
US-1,024,6428 Insensitive plasticizer and melt-castable energetic material
A method and compound includes mixing dichloroglyoxime with an alcohol containing an alkyne functional group in methanol to create a mixture; adding a salt...
US-1,024,6427 Derivatives of 1,2,3-triazolyl cyclohexan-1-ol and its use
1,2,3-triazolyl cyclohexanol derivatives have been disclosed and their use as ligands accelerating the copper(I)-catalyzed azide-alkyne cycloaddition and the...
US-1,024,6426 Triazole compounds as T-type calcium channel blockers
The invention relates to compounds of formula (I) ##STR00001## wherein X, Y, R.sup.1, R.sup.2, (R.sup.4).sub.n, and (R.sup.5).sub.m are as defined in the...
US-1,024,6425 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
The present invention relates compounds of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well...
US-1,024,6424 Substituted quinazoline compounds and methods of use thereof
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have one of the following structures (I), (II) or (III): ...
US-1,024,6423 Process for preparing statin precursor
The present invention relates to a process for preparing a statin precursor, which process comprises a first reaction step, wherein a ...
US-1,024,6422 Heterocyclic compounds and use thereof in medicine and in cosmetics
The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The...
US-1,024,6421 Indazolyl- and indolyl-benzamide derivatives
The invention relates to indazolylbenzamide, indolylbenzamide, benzo[d]imidazolyl-benzamide, and benzo[d]triazolylbenzamide derivatives of formula ##STR00001##...
US-1,024,6420 Pyrazole derivatives
The present invention relates to novel pyrazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the...
US-1,024,6419 Liver X receptor (LXR) modulators
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of LXR-associated diseases, disorders or...
US-1,024,6418 Crystal form of lenvatinib methanesulfonate salt and preparation method thereof
The present disclosure relates to a novel crystalline form of lenvatinib mesylate and the preparation method thereof. The novel crystalline form of mesylate of...
US-1,024,6417 Picolinamides as fungicides
This disclosure relates to picolinamides of Formula I and their use as fungicides. ##STR00001##
US-1,024,6416 Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides
Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl...
US-1,024,6415 Process for preparing carbazoles
A process for preparing one or more carbazoles comprising (a) contacting one or more compounds represented by formula (1) below with diboron reagents in the...
US-1,024,6414 Allosteric modulators of CB1 cannabinoid receptors
The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the...
US-1,024,6413 Selective FKBP51 ligands for treatment of psychiatric disorders
The present invention relates to compounds having a selective FKBP51 ligand scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical...
US-1,024,6412 Chemical film on substrate and method of forming the same, method of forming paracyclophane containing...
The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding...
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