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Patent # Description
US-1,025,1897 GLUT4 endocytosis inhibitor
The present invention provides a therapeutic drug for diabetes containing 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine (DOPE) as an active ingredient,...
US-1,025,1896 Compositions for improving cell viability and methods of use thereof
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and...
US-1,025,1895 Topical compositions and methods for treating psoriasis
Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.
US-1,025,1894 Anticonvulsant activity of steroids
The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid,...
US-1,025,1893 N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators
The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), ##STR00001## wherein A.sup.1, Y and Z all...
US-1,025,1892 Bicyclic heterocycles as FGFR4 inhibitors
The present disclosure relates to bicyclic heterocycles of Formula (I'), and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 and/or...
US-1,025,1891 Aprepitant oral liquid formulations
A liquid pharmaceutical compositions comprising Aprepitant is preferably prepared as an oral suspension dosage form for the prevention and control of acute and...
US-1,025,1890 Use of parthenolide derivatives as antileukemic and cytotoxic agents
The present invention provides compounds of the formula (I) ##STR00001## wherein: X.sub.1, X.sub.2 and X.sub.3 are heteroatoms; R.sub.4, R.sub.5, R.sub.6,...
US-1,025,1889 Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
Compounds of Formula I: ##STR00001## and salts thereof in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, Y and n have the meanings given in the specification,...
US-1,025,1888 Method of treating pancreatic cancer
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or...
US-1,025,1887 Methods and compositions to reduce oxidative stress
The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention...
US-1,025,1886 4-anilinoquinazoline derivative and albumin conjugates thereof
a pharmaceutical composition for preventing, treating, or ameliorating one or more symptoms of a malignant tumor associated with EGFR mutation and/or K-RAS...
US-1,025,1885 Azole antifungal compositions
The present invention relates generally to antifugal compositions. In an embodiment, the antifungal compositions are effective for application to nails and...
US-1,025,1884 Treatment of cancer and benign proliferative disorders
Disclosed herein are compositions comprising lopinavir alone or in combination with ritonavir for use as a medicament in the treatment of cancer or benign...
US-1,025,1883 Methods and formulations for modulating Lyn kinase activity and treating related disorders
The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically...
US-1,025,1882 Aza-pyridone compounds and uses thereof
Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same....
US-1,025,1881 Particulate materials
Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered...
US-1,025,1880 Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory...
Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes,...
US-1,025,1879 Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
US-1,025,1878 Polysubunit opioid prodrugs resistant to overdose and abuse
The invention provides compositions and methods for the treatment or prevention of pain. The invention provides constructs whereby hydrolysis of the construct...
US-1,025,1876 Method for treating tumour, pharmaceutical composition and medicinal kit
The present invention provides 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]me- thyl]cyclopro-pylamine used for combating a tumor....
US-1,025,1875 Atropine pharmaceutical compositions
The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most...
US-1,025,1874 Crystalline forms of a JAK inhibitor compound
The present invention provides crystalline hydrates of the oxalate and succinate salts of ...
US-1,025,1873 Methods of treating fabry patients having renal impairment
Provided are methods for treatment of Fabry disease in a patient having renal impairment and/or elevated proteinuria. Certain methods comprise administering to...
US-1,025,1872 Multisubstituted aromatic compounds as serine protease inhibitors
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or...
US-1,025,1871 Compositions and methods for treatment of edema
Provided are pharmaceutical compositions and methods of treating or preventing edema, using an anti-T cell agent, an anti-TGF-.beta.1 agent, or an...
US-1,025,1870 Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating GPR30/GPER activity
The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for...
US-1,025,1869 Compositions and methods of inhibiting metallo-.beta.-lactamases
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one...
US-1,025,1868 Benzothiazolone compound
The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form ##STR00001## a method for manufacturing the...
US-1,025,1867 Dosing regimen for a selective S1P.sub.1 receptor agonist
The present invention relates to a dosing regimen for a selective S1P.sub.1 receptor agonist, whereby the selective S1P.sub.1 receptor agonist is administered...
US-1,025,1866 Pharmaceutical nanosuspension
The present invention in general relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one active ingredient and at least one...
US-1,025,1865 Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists
Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha-2...
US-1,025,1864 Indole derivatives useful as glucagon receptor antagonists
The present invention is directed to indole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of...
US-1,025,1863 Parasiticidal compositions comprising indole derivatives, methods and uses thereof
The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative...
US-1,025,1862 Cosmetic composition containing hydroxy pyranone derivative compound for promoting differentiation of adipocytes
The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the...
US-1,025,1861 Methods for treating burn and scar injury using tocotrienol compositions
The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the...
US-1,025,1860 Compounds for bone healing
Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound...
US-1,025,1859 Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites...
US-1,025,1858 Composition for treating fungal infections in nails
A pharmaceutically active composition suitable for topical application to the nails contains undecylenic acid and tolnaftate. The composition also employs a...
US-1,025,1857 Azelaic acid esters in the treatment of insulin resistance
A method of treating insulin resistance includes administering to a subject a pharmaceutical composition comprising diethyl azelate. For example, a method of...
US-1,025,1856 Methods of treating neurodevelopmental diseases and disorders
The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans...
US-1,025,1854 S-(carboxymethyl)-cysteine pharmaceutical compound and preparation method and use thereof
Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an ...
US-1,025,1853 Synergistic famciclovir and celecoxib combination therapy for functional somatic syndromes
The present invention relates to methods of treating fibromyalgia, by administering a therapeutically-effective combination of an antiviral component and a...
US-1,025,1852 Composition and methods for treatment of lung disorders characterized by cholesterol dysregulation
Disclosed are compositions and methods for treating a condition characterized by a dysregulation in macrophage lipid homeostasis. The disclosed methods may...
US-1,025,1851 Bicyclic analgesic compounds
Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic...
US-1,025,1850 Process for preparation of cysteamine bitartrate
The present invention provides process for preparation of cysteamine bitartrate comprising reacting cysteamine or its salt with tartaric acid. The present...
US-1,025,1849 Sublingual compositions including epinephrine nanoparticles
The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions for the treatment of conditions...
US-1,025,1848 Process for producing a stable low concentration, injectable solution of noradrenaline
In a first aspect, the present invention relates to a process for producing a stable, injectable solution with low content of noradrenaline, which includes...
US-1,025,1847 Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)b- ...
Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of ...
US-1,025,1846 Oral combination for the prevention and treatment of bladder, pelvic and urogenital apparatus pathologies
The invention describes a pharmaceutical association of active ingredients comprising: curcumin, quercetin, chondroitin sulfate and hyaluronic acid, used for...
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