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Patent # Description
US-1,029,4317 Pressure sensitive adhesives with amphiphilic copolymers
A silicone pressure sensitive adhesive with amphiphilic copolymers for maintaining adhesion in a moist environment. The amphiphilic copolymers for silicone...
US-1,029,4316 Silica supports with high aluminoxane loading capability
Olefin polymerization catalyst systems having high aluminoxane loading and methods for making and using them are disclosed herein.
US-1,029,4315 Polyacrylic acid (salt)-based water absorbent resin and method for producing same
A method for producing a polyacrylic acid (salt)-based water absorbent resin, sequentially including the steps of: storing or producing acrylic acid; mixing...
US-1,029,4314 Functionalized elastomeric polymer compositions, their preparation methods and crosslinked rubber compositions...
The invention relates to an elastomeric polymer composition and its preparation. The polymer composition includes, in combination, a single terminally modified...
US-1,029,4313 Process for preparing aminomethylated bead polymers
Aminomethylated bead polymers for use as ion exchangers, especially as anion exchangers, or for the preparation of chelate resins, are prepared in the presence...
US-1,029,4312 Olefin polymerization catalyst system comprising mesoporous organosilica support
A catalyst system comprising a combination of: 1) an activator; 2) one or more metallocene catalyst compounds; 3) a support comprising an organosilica material,...
US-1,029,4311 Ziegler-natta catalysts doped with non-Group IV metal chlorides
A process may include contacting ethylene monomer with Ziegler-Natta catalyst to form polyethylene. The Ziegler-Natta catalyst may be formed by contacting an...
US-1,029,4310 Photocurable composition
An object of the present invention is to provide a photocurable composition from which a cured product having high concealing property is obtained by...
US-1,029,4309 Extraction of polyisoprene with high molar mass
The invention relates to a method for extracting high-quality polyisoprene by grinding plants via rotary shearing using a device comprising at least one rotor...
US-1,029,4308 Method for isolation of polysaccharides
A process for the isolation of modified polysaccharide product from potato, in particular a polysaccharide product that can be used as an immunomodulatory is...
US-1,029,4307 Methods for producing fabs and bi-specific antibodies
The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light...
US-1,029,4306 Affinity ligands and methods relating thereto
Affinity ligands useful for mild elution affinity chromatography, including affinity ligands specific for immunoglobulins M, A, and E, are disclosed as are...
US-1,029,4305 Method for treating a GD2 positive cancer
Preparations and methods for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient, wherein the patient is...
US-1,029,4304 Chimeric antigen receptors targeting B-cell maturation antigen
The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells...
US-1,029,4303 Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide...
Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the...
US-1,029,4302 Therapeutic method and medicament for HTLV-1 associated myelopathy
The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for...
US-1,029,4301 Anti-human BDCA-2 antibody
[Problem] Provided is an anti-human BDCA-2 antibody for preventing or treating an autoimmune disease by binding to a human BDCA-2 to control the function of a...
US-1,029,4300 Antibody constructs for DLL3 and CD3
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and...
US-1,029,4299 Immunological reagents
This disclosure relates to binding agents with specificity for programmed cell death 1 (PD-1) and to methods for using the same to treat, prevent and/or...
US-1,029,4298 Human PAC1 antibodies
Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments...
US-1,029,4297 Methods for treatment using anti-NMU agents
The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are...
US-1,029,4296 Treatment for neoplastic diseases
Administration of a mAb that specifically binds IL-1.alpha. is useful for treating tumor-associated diseases in human subjects.
US-1,029,4295 Methods for modulating angiogenesis of cancers refractory to anti-VEGF treatment
A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and...
US-1,029,4294 Synthetic antibodies to BAX and uses thereof
Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX...
US-1,029,4293 Human monoclonal antibody with specificity for dengue virus serotype 1 E protein and uses thereof
Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing...
US-1,029,4292 Neutralizing anti-influenza B antibodies and uses thereof
The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing...
US-1,029,4291 Platelet targeted treatment
The present disclosure relates to compositions and methods for targeting expression of exogenous genes to platelets. In particular, the present disclosure...
US-1,029,4290 Polypeptides derived from calcitonin receptors and methods of use
The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for...
US-1,029,4289 Soluble fibroblast growth factor receptor 3 (SFGFR3) polypeptides and uses thereof
The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to...
US-1,029,4288 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,029,4287 Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases
This invention provides for a fusion protein between an IL2.alpha..beta..gamma. Selective Agonist protein (IL2 Selective Agonist) and a IgG Fc protein using a...
US-1,029,4286 Chimeric inhibitor molecules of complement activation
The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of...
US-1,029,4285 Modification and compositions of human secretoglobin proteins
Novel compositions of recombinant human CC10 protein have been generated by chemically modifying the pure protein in vitro. Several new synthetic preparations...
US-1,029,4284 Method for preparing C1q recombinant protein
The present invention relates to a method for recombinant production of a C1q protein or a variant of the C1q protein, in which the protein is recovered from an...
US-1,029,4283 Single-domain antibodies with improved thermal stability under cytoplasmic expression
Methods of producing a single-domain antibody (sdAb) include causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is...
US-1,029,4282 Antibody capable of binding to intranuclear protein of influenza virus, composite, detection device and method...
The present invention is an antibody including an amino acid sequence, wherein the amino acid sequence includes, in an N- to C-direction, the following...
US-1,029,4281 High-transduction-efficiency rAAV vectors, compositions, and methods of use
The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or...
US-1,029,4280 Constrained proteins and uses therefor
A fusion protein comprising an N-terminal portion and a C-terminal portion, wherein the N-terminal portion is a heterologous protein of interest which includes...
US-1,029,4279 Stabilized soluble pre-fusion RSV F polypeptides
This disclosure provides stable pre-fusion respiratory syncytial virus (RSV) F polypeptides, immunogenic compositions comprising the polypeptides, and uses...
US-1,029,4278 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O,...
US-1,029,4277 Stabilised FMDV capsids
The present invention relates to the stabilization of foot-and-mouth disease virus (FMDV) capsids, by specific substitution of amino acids in a specific region...
US-1,029,4276 Process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin
The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the...
US-1,029,4275 Site-selective functionalization of glycopeptide antibiotics
Site-selective functionalized glycopeptide antibiotics, methods of making and using are described herein. The compounds exhibit improved activity against...
US-1,029,4274 Polypeptide ligands specific for plasma kallikrein
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between...
US-1,029,4273 Macrocyclic peptidomimetics for alpha-helix mimicry
Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and...
US-1,029,4272 Peptides with antagonistic activities against natural CXCR4
A peptide effective in blocking the CXC-chemokine receptor 4 (CXCR4) mediated HIV-1 NL4-3 (X4-tropic) infection with an IC.sub.50 value of less than 50 .mu.M.
US-1,029,4271 Compound, composition, and method for detecting caspase activity and/or apoptosis
Molecular probe suitable for quantification of caspase activity in vivo using positron emission tomography (PET). Embodiments of the present invention can...
US-1,029,4270 Branched linker for protein drug conjugates
The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a...
US-1,029,4269 Dipeptidyl ketoamide compounds and their use for the treatment and/or prevention of fat accumulation
The present invention relates to the use of dipeptidyl ketoamide compounds for preventing accumulation of triglycerides in adipose tissue or for reducing the...
US-1,029,4268 Methods for separating and purifying endogenous, exogenous and recombinant proteins/peptides from plants and...
The present invention relates to recombinant proteins/peptides from plant and animal materials, compositions comprising the proteins/peptides and methods for...
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