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Patent # Description
US-1,029,4267 Membrane with surface channels
Membranes having parallel channels in a surface of the membranes, wherein the channels have side walls having rough surfaces; filters and devices including at...
US-1,029,4266 Engineering surface epitopes to improve protein crystallization
The invention provides for methods and systems for engineering target proteins, based on protein sequence characteristics that influence the likelihood of...
US-1,029,4265 Functionalized bile acids for therapeutic and material applications
The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one...
US-1,029,4264 Oxysterol-therapeutic agent derivative for bone healing
Oxysterol-therapeutic agent derivatives or OXY133-therapeutic agent derivative compounds and methods of synthesizing the same are provided for use in promoting...
US-1,029,4263 Transition metal molybdotungsten oxy-hydroxide
A hydroprocessing catalyst has been developed. The catalyst is formed from a unique transition metal molybdotungsten oxy-hydroxide material. The hydroprocessing...
US-1,029,4262 7-deazapurine nucleosides for therapeutic uses
The invention provides compounds of formula I, wherein R.sub.1, R.sub.2 and R.sub.3 have values defined in the specification and a pharmaceutically acceptable...
US-1,029,4261 Compound, nucleic acid, labeling substance, and detection method
The present invention provides a compound represented by the following chemical formula (I); a tautomer or stereoisomer of the compound; or a salt of the...
US-1,029,4260 Tetracyclic anthraquinone derivatives
Disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-1,029,4259 Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a...
US-1,029,4258 Functionalization and purification of molecules by reversible group exchange
Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups,...
US-1,029,4257 Methods for preparing ruthenium carbene complexes and precursors thereto
Methods of preparing ruthenium carbene complex precursors are disclosed herein. In some embodiments, the methods include reacting a ruthenium refinery salt with...
US-1,029,4256 Phosphine oxide alkyl amide substituted heteroaryl compounds as modulators of IL-12, IL-23 and/or IFN alpha...
Compounds having the following formula I: ##STR00001## or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined...
US-1,029,4255 Multifunctional crosslinking agent, crosslinked polymer, and method of making same
A multifunctional crosslinking agent, a crosslinked polymer, and a method of making the same are disclosed. The multifunctional crosslinking agent, which may be...
US-1,029,4254 DNA/Dithiocarbamato phosphine metal complex
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
US-1,029,4253 Siloxane-containing phospholipids, compositions and uses thereof
The present application relates to siloxane-containing phospholipids such as the compounds of Formula I, methods of preparation, compositions and uses thereof. ...
US-1,029,4252 Cyclic germanium compounds and applications thereof
The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds...
US-1,029,4251 Process for preparing alkoxysilanes
A transesterification process for preparing alkoxysilane includes removal of metal transesterification catalyst from the alkoxysilane transesterification...
US-1,029,4250 Organoaminosilanes and methods for making same
Organoaminosilanes, such as without limitation di-iso-propylaminosilane (DIPAS), are precursors for the deposition of silicon containing films such as...
US-1,029,4249 Boronic acid derivatives and therapeutic uses thereof
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to...
US-1,029,4248 Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
US-1,029,4247 Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
US-1,029,4246 Substituted boronic acids and boronate esters as immunoproteasome inhibitors
Compounds of formula (I) are inhibitors of LMP7 and can be employed, inter alia, for the treatment of an autoimmune disorder or hematological malignancies. ...
US-1,029,4245 High performance organic electrodes for secondary batteries
The present disclosure relates to a compound of general Formula (1) which can be used as an electrode material, an electrode comprising said compound, and a...
US-1,029,4244 2,3-dihydro-thiazolo[3,2-A]pyridin-5-one derivatives, intermediates thereof, and their use as antibacterial agents
The disclosure relates to certain novel substituted ring-fused thiazolino 2-pyridines of Formula I, to processes for preparing such compounds, to their use in...
US-1,029,4243 Bicyclic compounds as pesticides
The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.
US-1,029,4242 Diaryl macrocycle polymorph
This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo- ...
US-1,029,4241 Substituted polycyclic pyridone derivatives and prodrugs thereof
The present invention provides the following compounds having anti-viral activity. ##STR00001## A.sup.1 is CR.sup.1AR.sup.1B, S or O; A.sup.2 is ...
US-1,029,4240 Fluorescent probe for detecting calpain activity
[Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general...
US-1,029,4239 Ertugliflozin co-crystals and process for their preparation
The present invention relates to processes for the preparation of an ertugliflozin-L-pyroglutamic acid (1:1) and co-crystal ertugliflozin-L-proline (1:1)...
US-1,029,4238 Isosorbide diester as pearlizing agent and opacifier
A description is given of a composition comprising at least one isosorbide diester, at least one isosorbide monoester and at least one fatty acid, and also of a...
US-1,029,4237 Bicyclic heterocyclic amide derivative
The present invention provides a bicyclic heterocyclic amide derivative of formula (1) wherein ring Q.sup.1 is optionally-substituted C.sub.6-10 aryl group,...
US-1,029,4236 Compounds as rearranged during transfection (RET) inhibitors
This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing...
US-1,029,4235 Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof
The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the...
US-1,029,4234 HIV inhibitor compounds
The invention provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof as described herein. The invention also provides...
US-1,029,4233 Treatment of H. pylori infections using MTAN inhibitors
Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise...
US-1,029,4232 Crystalline forms of a Bruton's tyrosine kinase inhibitor
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
US-1,029,4231 Crystalline forms of a Bruton's tyrosine kinase inhibitor
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
US-1,029,4230 3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
Disclosed are chemical entities of Formula (I): ##STR00001## wherein R.sup.1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also...
US-1,029,4229 Heteroaryl substituted aminopyridine compounds
Disclosed are compounds of Formula (I) or salts thereof, wherein HET is a heteroaryl selected from pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3 d]pyrimidinyl,...
US-1,029,4228 Breathing control modulating compounds, and methods of making and using same
The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need...
US-1,029,4227 Compounds
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R.sub.1 is...
US-1,029,4226 Small molecule inhibitors of the JAK family of kinases
2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)ace- tonitrile compounds, pharmaceutical compositions containing them, methods of making...
US-1,029,4224 Lyophilized composition of a diazabicyclooctane compound and process of producing the same
A process for producing crystals of a compound represented by the following formula (I): ##STR00001## by crystallizing the compound from an aqueous solution...
US-1,029,4223 Quinolone derivatives as fibroblast growth factor receptor inhibitors
Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are...
US-1,029,4222 Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
US-1,029,4221 1, 3, 4-thiadiazole compounds and their use in treating cancer
The specification relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, where Q, R, R.sup.1 and R.sup.2 have any of...
US-1,029,4220 Compositions and methods for treating retinal degradation
The present disclosure relates to nucleosides, such as ##STR00001## compositions, and methods useful for treating retinal damage and/or retinal...
US-1,029,4219 Ledipasvir crystal form and preparation method thereof
The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate...
US-1,029,4218 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity
Novel 4,6-disubstituted aminopyrimidine derivatives with the following structure (I) ##STR00001## have anti-HIV activity.
US-1,029,4217 Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators
The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric...
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